ArticleInternational journal of general medicine2026
Downregulated LINC02381 Predicts Tumor Progression and Correlates with Poor Survival in Gastric Cancer.
Article in International journal of general medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: The elevated incidence and mortality rates of gastric cancer (GC) highlight the urgent need to identify novel prognostic biomarkers. In this study, we aimed to evaluate the expression of LINC02381 in GC tissues and its correlation with clinicopathological features, and to assess its prognostic significance. Methods: The expression of LINC02381 was assessed in 49 cases of GC tissues and noncancerous gastric tissues using real-time PCR. The correlation between the expression of LINC02381 and the clinicopathological parameters of GC patients was analyzed by in situ hybridization histochemistry (ISHH) in 78 GC tissues. Subsequently, univariate and multivariable Cox regression analysis, and Kaplan-Meier survival analysis were performed to correlate with clinicopathological variables. Results: We found the expression of LINC02381 was decreased in GC tissues ( Conclusion: LINC02381 is downregulated in GC tissues, and its low expression is associated with malignant progression and shorter survival. Although not an independent prognostic factor, it may serve as a potential adjunct prognostic indicator for GC.
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