ArticleFrontiers in cardiovascular medicine2026
Anxiety, depression and health-related quality of life in patients with thoracic aortic disease: a longitudinal study in a cardiothoracic outpatient clinic.
Article in Frontiers in cardiovascular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Thoracic aortic diseases (TAD) require complex surgical and longitudinal follow-up care. Evidence on health-related quality of life (HRQoL) and psychological distress in real-world TAD outpatient cohorts remains limited. Objective: To describe longitudinal trajectories of HRQoL and psychological distress in patients with TAD and to examine associations with key demographic and clinical variables. Methods: We retrospectively analyzed 111 patients (256 visits, 2023-2025). Primary outcomes were EQ-5D-5L index values, EQ-VAS scores, and PHQ-4 total scores. Linear mixed-effects models (random intercepts for patient ID) and logistic regression (PHQ-4 ≥6) were used to account for repeated measures. Primary predictors included sex, surgical status, and time since surgery; age and visit number were examined exploratorily. Results: Median EQ-5D-5L was 0.71 (IQR 0.55-0.88), EQ-VAS 70 (60-80), and PHQ-4 3 (1-5). Time since surgery predicted HRQoL improvement ( Conclusions: Preoperative TAD patients reported lower HRQoL and higher distress, while postoperative recovery was associated with gradual improvement. Findings reflect real-world patterns in a mixed pre-/postoperative outpatient cohort and support integrating brief psychosocial screening into routine TAD follow-up.
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