ArticleCurrent ophthalmology reports2026
Acute Retinal Necrosis versus Progressive Outer Retinal Necrosis.
Article in Current ophthalmology reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
3 authors.
Funding
Abstract
Purpose of Review: This review aims to provide a comprehensive comparison between acute retinal necrosis (ARN) and progressive outer retinal necrosis (PORN), two sight-threatening manifestations of herpetic viral retinopathies emphasizing how immune status shapes presentation, diagnosis, management, and prognosis. Recent Findings: Recent studies suggest that ARN and PORN represent a spectrum influenced largely by host immune status rather than distinct diseases. Ultra-widefield imaging improves detection of far-peripheral lesions, while PCR of aqueous or vitreous enables rapid etiologic confirmation. In ARN, high-bioavailability oral antivirals, often with adjunct intravitreal injections, accelerate lesion regression and reduce fellow-eye involvement. In PORN, monotherapy performs poorly; combined intensive intravitreal and systemic therapy improves local control but vision remains limited in advanced immunosuppression. Summary: Prompt differentiation based on inflammatory signs, lesion morphology, and host immunity directs therapy. ARN generally responds to systemic agents yet carries substantial detachment risk; PORN progresses quickly with worse outcomes despite aggressive care. Early diagnosis coordinated medical-surgical management, and close surveillance are critical; priorities include optimal dosing and duration of antiviral therapies as well as adjunctive anti-inflammatory strategies.
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Registered trials
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