ArticleFrontiers in microbiology2026
Effects of succinate supplementation on rumen fermentation, microbiota, and propionate-associated metabolism
Article in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Succinate is an intermediate in the ruminal succinate-propionate pathway, but its direct effects as an exogenous additive on rumen fermentation, bacterial community structure, and energy-related metabolites remain insufficiently characterized. This study evaluated whether graded succinate supplementation changes Methods: Rumen fluid collected from three fistulated Chinese Holstein cows was pooled within each weekly fermentation run and incubated with alfalfa substrate and sodium succinate at 0, 4, 8, or 12 mmol/L. Gas-production kinetics, fermentation characteristics, bacterial community composition, targeted energy metabolites, and correlation networks were analyzed. Results: Succinate supplementation altered gas-production kinetics, with 24-h and potential gas production peaking at 8 mmol/L. Acetate, propionate, butyrate, and total VFA concentrations increased, whereas pH and NH Discussion: These findings indicate that succinate supplementation was associated with increased propionate concentration and coordinated changes in bacterial taxa and targeted metabolites related to propionate-associated metabolism
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