ReviewInfection and drug resistance2026
Deglycosylation at War: Host N-Glycoprotein Remodeling in Infection and Immunity.
Review in Infection and drug resistance, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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0 citing papers in PubMed.
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
N-glycan remodeling, including the hydrolysis of both glycopeptide linkages and glycosidic linkages, serves as a critical regulatory mechanism in biological processes including molecular recognition and immune responses. Growing evidence reveals that the dynamic balance between host protein glycosylation and N-glycan remodeling significantly influences the outcomes of infectious diseases. During infection, host N-glycoproteins remodeling can be driven either by the host as a defense strategy or by pathogens as an offensive mechanism. This review systematically examines how both host- and pathogen-induced N-glycan remodelling events affect infection outcomes. We highlight the dual functionality: host-driven remodeling often enhances immune recognition and pathogen clearance, whereas pathogen-driven remodeling facilitates adhesion, immune evasion, and nutrient acquisition. By integrating evidence from direct enzymatic N-glycan remodeling and indirect glycan-processing models, this review offers a novel perspective on glycan-mediated microbial-host interactions, highlighting how targeted modulation of these processes may advance therapeutic strategies against infectious diseases.
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