Evidence map›Paper›PMID 42445418›Full record

ArticleTranslational cancer research2026

Recombinant adeno-associated virus-mediated HSV-TK/GCV gene therapy for ovarian cancer: an experimental study.

Yanqiang Xiong, Wu Zhou, Jianlin Yang, Yajun Li, Ye Shen, Yafeng Lv, Chan Meng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational cancer research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yanqiang Xiong *Department of Obstetrics and Gynecology, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science &Technology, Wuhan, China.
Wu Zhou *Department of Obstetrics and Gynecology, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science &Technology, Wuhan, China.
Jianlin YangHubei Key Laboratory of Tumor Microenvironment and Immunotherapy, China Three Gorges University, Three Gorges University Basic Medical College, Yichang, China.
Yajun LiDepartment of Obstetrics and Gynecology, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science &Technology, Wuhan, China.
Ye ShenDepartment of Obstetrics and Gynecology, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science &Technology, Wuhan, China.
Yafeng LvHubei Key Laboratory of Tumor Microenvironment and Immunotherapy, China Three Gorges University, Three Gorges University Basic Medical College, Yichang, China.
Chan MengDepartment of Obstetrics and Gynecology, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science &Technology, Wuhan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Ovarian cancer is one of the most aggressive malignancies of the female reproductive system, and the 5-year survival rate is lower than 45%. This study aimed to evaluate a selectively targeted adeno-associated virus (AAV) vector for ovarian cancer, and to investigate its specificity and antitumor efficacy in order to provide experimental evidence for gene therapy of ovarian cancer. Methods: The epithelial cell adhesion molecule (EpCAM)-specific binder EC1 was fused into the AAV2 capsid protein VP2 to construct an EpCAM-targeted recombinant vector (AAV2M Results: AAV2M Conclusions: AAV2M

Indexed as

Adeno-associated virus (AAV)epithelial cell adhesion molecule (EpCAM)gene therapyovarian cancer

Identifiers

PMID42445418
PMCPMC13357089

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.