ArticleTranslational cancer research2026
Endoplasmic reticulum stress promotes colorectal cancer proliferation by regulating autophagy via XBP1s.
Article in Translational cancer research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: XBP1s, a key downstream molecule of endoplasmic reticulum stress (ERS), is widely involved in processes such as proliferation, invasion, and apoptosis in cancer. However, the role and underlying mechanism of XBP1s in colorectal cancer (CRC) remain poorly understood. We hypothesize that XBP1s plays a critical role in promoting CRC proliferation through the regulation of autophagy. Therefore, this study aims to investigate the expression, biological functions, and underlying mechanisms of XBP1s in colorectal cancer, opening up new directions for targeted tumor therapy. Methods: Based on The Cancer Genome Atlas (TCGA) database, the expression of Results: The expression of XBP1s was significantly higher in CRC tissues compared to normal tissues and was significantly associated with poor prognosis in CRC patients. Knockdown of XBP1s expression Conclusions: Our findings indicate that interference with XBP1s expression can inhibit the malignant proliferation of CRC by suppressing the autophagy signaling pathway. Targeting XBP1s may represent a novel therapeutic strategy for the diagnosis and treatment of CRC patients.
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