ArticleTranslational cancer research2026
Identification of telomere-related gene signatures for immune cell infiltration and prognosis in hepatocellular carcinoma.
Article in Translational cancer research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Hepatocellular carcinoma (HCC) is a common malignancy with poor clinical outcomes. Telomere maintenance is crucial for tumor cell proliferation, yet the role of telomere-related genes (TRGs) in HCC prognosis remains unclear. This study aimed to identify TRG-based prognostic signatures and to evaluate their associations with immune cell infiltration and drug responsiveness in HCC. Methods: TRGs were analyzed for survival significance with The Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GEO) database. A prognostic model was constructed using sequential statistical approaches. A nomogram incorporating clinical parameters was generated for patient survival estimation. Risk stratification classified HCC patients. Model accuracy was assessed by receiver operating characteristic (ROC) curves. Immune cell infiltration and drug responsiveness were compared across groups. Results: A seven-gene prognostic signature ( Conclusions: This study identified significant associations between DEGs and HCC prognosis, highlighting their potential as biomarkers. The findings suggest applications for prognostic scoring systems in clinical decision-making, therapeutic regimen selection and immunotherapy approaches for HCC patients.
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