ArticleIJU case reports2026
Selective Tumor-to-Tumor Metastasis of the LCNEC Component of a Combined Lung Carcinoma to Clear Cell Renal Cell Carcinoma Despite a Concurrent Meningioma.
Article in IJU case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Tumor-to-tumor metastasis is a rare pathological phenomenon. We report an extremely rare case in which the large cell neuroendocrine carcinoma (LCNEC) component of a combined lung carcinoma selectively metastasized to clear cell renal cell carcinoma (RCC) despite the presence of a concurrent meningioma. Case Presentation: A 65-year-old man with recurrent meningioma was incidentally found to have a right lung nodule and a left renal mass. The lung tumor was diagnosed as combined LCNEC and adenocarcinoma. Partial nephrectomy revealed clear cell RCC containing a discrete metastatic focus. Hematoxylin and eosin staining showed no definitive adenocarcinoma features, whereas immunohistochemistry demonstrated CD56 and synaptophysin positivity, strongly suggesting metastasis from the LCNEC component. Conclusion: This highly selective tumor-to-tumor metastasis pattern is extremely rare, and to our knowledge, this is the first report describing selective LCNEC metastasis to RCC while sparing a synchronous meningioma.
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