ArticleRSC mechanochemistry2026
From ball-milling to bead-milling technology: rapid optimization and scale-up of a one-pot Wittig olefination-Diels-Alder reaction sequence using an agitator bead mill.
Article in RSC mechanochemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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5 authors.
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Abstract
Mechanochemical methods offer a sustainable alternative to traditional solution-based synthesis, yet their scalability beyond laboratory-scale ball mills remains a challenge and often requires lengthy re-optimization for larger scales. Herein, we report the rapid batch translation of a one-pot Wittig olefination-Diels-Alder reaction sequence from a ball mill to an agitator bead mill (DYNO®-MILL RESEARCH LAB), achieving a scale-up from milligram to multi-gram quantities. Crucially, this translation was accomplished with minimal on-the-fly optimization, requiring only a few bead-milling runs to identify suitable operating conditions and perform the transformation in batch mode with good efficiency. Our results provide a practical case study for the scalability of mechanochemical reactions by using bead-milling technology and highlight the potential of bead-milling devices for future process development.
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Registered trials
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