Desflurane post-conditioning inhibits HMGB1 nucleocytoplasmic translocation via the SIRT1/HMGB1 axis to attenuate hepatic ischemia-reperfusion-induced acute lung injury in young rats.

Yimei Cao, Yingli Cao, Hongyin Du, Hengchang Ren, Xiangming Che

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Article in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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5 · Who and what money

Authors and funding

5 authors.

Yimei CaoDepartment of Anesthesiology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, China.

Yingli CaoDepartment of Anesthesiology, Peking University Third Hospital, Beijing, China.

Hongyin DuDepartment of Anesthesiology, Tianjin First Central Hospital, Tianjin, China.

Hengchang RenDepartment of Anesthesiology, Tianjin First Central Hospital, Tianjin, China.

Xiangming CheDepartment of Anesthesiology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute lung injury (ALI) is a common clinical complication in pediatric patients undergoing perioperative liver transplantation, and therapeutic approaches are limited. While desflurane exhibits organ-protective potential, its specific efficacy against hepatic ischemia-reperfusion (HIR)-induced ALI in the developing lung, as well as the underlying molecular mechanisms, remain poorly understood. This study aimed to investigate the protective effects of desflurane and delineate the regulatory pathways involved. 2 week-old Sprague-Dawley rats were subjected to 70% warm HIR to simulate pediatric liver transplantation. Desflurane was administered at the onset of reperfusion. The severity of lung injury, inflammatory responses, and relevant intracellular signaling pathways were evaluated using histological and molecular analyses.

Indexed as

acute lung injurydesfluranehepatic ischemia-reperfusionhigh mobility group protein B1silent information regulator 2 related enzyme 1

Identifiers

PMID42445242

DOI10.3389/fphar.2026.1847195

PMCPMC13357140

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.