Evidence map›Paper›PMID 42445220›Full record

ArticleImmunometabolism (Cobham, Surrey)2026

A loss of the cytosolic branched-chain aminotransferase, BCATc, enhances T

Tanner J Wetzel, Christie M Adam, Tanner J Kelm, Anna E Kotula, Madison E Fagan, Taha Z Khan, Anthony X Diehl, Melissa A Meyer, Jessica P Sanchez, Brian H Ladle and 1 more

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In one paragraph

Article in Immunometabolism (Cobham, Surrey), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Tanner J WetzelDepartment of Biochemistry and Nutrition, Des Moines University, West Des Moines, IA, USA.
Christie M AdamDepartment of Biochemistry and Nutrition, Des Moines University, West Des Moines, IA, USA.
Tanner J KelmDepartment of Biochemistry and Nutrition, Des Moines University, West Des Moines, IA, USA.
Anna E KotulaDepartment of Biochemistry and Nutrition, Des Moines University, West Des Moines, IA, USA.
Madison E FaganDepartment of Biochemistry and Nutrition, Des Moines University, West Des Moines, IA, USA.
Taha Z KhanDepartment of Biochemistry and Nutrition, Des Moines University, West Des Moines, IA, USA.
Anthony X DiehlDepartment of Biochemistry and Nutrition, Des Moines University, West Des Moines, IA, USA.
Melissa A MeyerDepartment of Immunology, Microbiology and Pathology, Des Moines University, West Des Moines, IA, USA.
Jessica P SanchezDepartment of Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University, Baltimore, MD, USA.
Brian H LadleDepartment of Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University, Baltimore, MD, USA.
Elitsa A AnanievaDepartment of Biochemistry and Nutrition, Des Moines University, West Des Moines, IA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: T-cell fate and function are profoundly shaped by microenvironmental nutrient availability. The branched-chain amino acid, leucine, is essential for T-cell function, with its uptake via the solute carrier family 7-member 5 transporter increasing upon activation. As the enzyme catalyzing the first step of leucine degradation, the cytosolic branched-chain aminotransferase (BCATc) is induced upon T-cell activation and subsequently acts as a negative regulator of T-cell activity. However, a major knowledge gap remains regarding how BCATc modulates T-cell function beyond activation, specifically within differentiated T helper cells. Methods: Novel T-cell conditional knockout mouse models of BCATc, and its mitochondrial isoenzyme, BCATm, were characterized and used as a source of in vitro or ovalbumin-induced CD4 Results: Loss of BCATc enhanced T Conclusions: BCATc is the dominant BCAT isoenzyme with immunoregulatory function in CD4

Indexed as

amino acidsBCATcBCATmleucineT-cell subsets

Identifiers

PMID42445220
PMCPMC13361958

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.