ArticleCurrent fungal infection reports2010
On the Roles of Calcineurin in Fungal Growth and Pathogenesis.
Article in Current fungal infection reports, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Host-induced gene silencing targeting the calcineurin ofFrontiers in plant science · 2025Article
- Roles of Elm1 in antifungal susceptibility and virulence in Candida glabrata.Scientific reports · 2020Article
- Calcineurin Regulates Conidiation, Chlamydospore Formation and Virulence inFrontiers in microbiology · 2020Article
- Phylogenetic analyses on the diversity of Aspergillus fumigatus sensu lato based on five orthologous loci.Mycopathologia · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Calcineurin is a calcium-activated phosphatase that controls morphogenesis and stress responses in eukaryotes. Fungal pathogens have adopted the calcineurin pathway to survive and effectively propagate within the host. The difficulty in treating fungal infections stems from similarities between pathogen and host eukaryotic cells. Use of calcineurin inhibitors such as cyclosporin A (CsA) or tacrolimus (FK506) in combination with antifungal drugs including azoles or echinocandins renders these drugs fungicidal, even towards drug-resistant species/strains, making calcineurin a promising drug target. Here we summarize the current understanding of the calcineurin pathway and its roles in governing growth and virulence of pathogenic fungi. We compare and contrast roles of calcineurin in fungal pathogens that infect humans (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.