Evidence map›Paper›PMID 42445198›Full record

ReviewFrontiers in immunology2026

Promising non-invasive biomarkers for kidney allograft monitoring: a mini review.

Luke Barr, Fareeha Mubin, John Friedewald, Sook Hyeon Park

Abstract readReview
In one paragraph

Review in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Luke BarrDepartment of Medicine, Division of Nephrology and Hypertension, Northwestern University, Feinberg School of Medicine, Chicago, IL, United States.
Fareeha MubinDepartment of Medicine, Division of Nephrology, Jefferson Einstein Philadelphia Hospital, Philadelphia, PA, United States.
John FriedewaldDepartment of Medicine, Division of Nephrology and Hypertension, Northwestern University, Feinberg School of Medicine, Chicago, IL, United States.
Sook Hyeon ParkDepartment of Medicine, Division of Nephrology and Hypertension, Northwestern University, Feinberg School of Medicine, Chicago, IL, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Significant advancements have been made in kidney transplantation, with a wealth of immunosuppressive and antimicrobial therapies that have significantly improved graft survival. Despite these accomplishments, the ability to promptly identify kidney allograft pathology for these therapies has been limited by the reliance on kidney biopsy as the gold-standard diagnostic modality, which is invasive. To overcome these limitations, non-invasive biomarkers have been developed over the past two decades. Donor-derived cell-free DNA, gene expression profiling, urinary chemokines, extracellular vesicles, microRNA, and Torque Teno Virus are candidates near or already in clinical use. This mini-review discusses the strengths and limitations of these biomarkers for the surveillance and prognostication of renal allografts.

Indexed as

BiomarkersGraft RejectionKidney TransplantationAllograftsAnimalsCell-Free Nucleic AcidsChemokinesExtracellular VesiclesGene Expression ProfilingGraft SurvivalHumansMicroRNAsBiomarkersCell-Free Nucleic AcidsChemokinesMicroRNAsdonor-derived cell-free DNAgene expression profileimmunologic monitoringkidney transplantnoninvasive biomarkersurine chemokines

Identifiers

PMID42445198
PMCPMC13357181

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.