Evidence map›Paper›PMID 42445178›Full record

ArticleFrontiers in immunology2026

Immunotherapeutic potential of PD-1 blockade in chronic Leishmania mexicana infection through the enhancement of progenitor-like CXCR5

Mariana Diupotex, Julián A Gajón, Laura C Bonifaz, Jaime Zamora-Chimal, Ingeborg Becker

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. T cell exhaustion in parasitic infections.Frontiers in immunology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mariana DiupotexUnidad de Investigación en Medicina Experimental, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad de México, Mexico.
Julián A GajónUnidad de Investigación Médica en Inmunología, Hospital de Pediatría, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de México, Mexico.
Laura C BonifazUnidad de Investigación Médica en Inmunoquímica, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de México, Mexico.
Jaime Zamora-ChimalUnidad de Investigación en Medicina Experimental, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad de México, Mexico.
Ingeborg BeckerUnidad de Investigación en Medicina Experimental, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad de México, Mexico.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diffuse cutaneous leishmaniasis (DCL), caused by

Indexed as

Immune Checkpoint InhibitorsLeishmania mexicanaLeishmaniasis, CutaneousProgrammed Cell Death 1 ReceptorAnimalsCD8-Positive T-LymphocytesChronic DiseaseFemaleHepatitis A Virus Cellular Receptor 2MiceMice, Inbred C57BLReceptors, CXCR5T-Cell ExhaustionCXCR5 protein, mouseHavcr2 protein, mouseHepatitis A Virus Cellular Receptor 2Immune Checkpoint InhibitorsPdcd1 protein, mouseProgrammed Cell Death 1 ReceptorReceptors, CXCR5anti-PD-1chronic infectioncutaneous leishmaniasisimmunotherapyprogenitor-like T cellsT-cell exhaustionterminally-differentiated T cells

Identifiers

PMID42445178
PMCPMC13357283

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.