Evidence map›Paper›PMID 42445171›Full record

ArticleFrontiers in immunology2026

Immunological and clinical characteristics of severe thrombocytopenia in neonates with Kasabach-Merritt phenomenon.

Cancan Li, Yang Li, Yan Huang, Yuanyuan Gao, Lili Li, Jinhui Hu, Ting Feng, Zhenhong Zhu, Haifeng Geng

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Cancan Li *Department of Neonatology, Children's Hospital of Soochow University, Suzhou, China.
Yang Li *Department of Clinical Laboratory, Children's Hospital of Soochow University, Suzhou, China.
Yan Huang *Department of Pharmacy, Children's Hospital of Soochow University, Suzhou, China.
Yuanyuan GaoDepartment of Clinical Laboratory, Children's Hospital of Soochow University, Suzhou, China.
Lili LiDepartment of Neonatology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, China.
Jinhui HuNeonatal Medical Center, Huai' an Maternity and Child Health Care Hospital, Huaian, China.
Ting FengDepartment of Ultrasonography, Children's Hospital of Soochow University, Suzhou, China.
Zhenhong ZhuDepartment of Burn and Plastic Surgery, Children's Hospital of Soochow University, Suzhou, China.
Haifeng GengDepartment of Neonatology, Children's Hospital of Soochow University, Suzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: This study aimed to characterize the immune profile of neonates with Kasabach-Merritt phenomenon (KMP) and to identify clinical features linked to severe thrombocytopenia in these patients. Methods: This multicenter retrospective study included neonates diagnosed with KMP based on established criteria. The peripheral blood lymphocyte subsets, complement levels, and humoral immunity were compared between KMP neonates and controls. KMP neonates were further divided into severe and non-severe groups based on whether the platelet count was <20 × 10 Results: A total of 32 KMP neonates were included (13 in the severe group and 19 in the non-severe group). Compared with controls, KMP neonates had reduced CD3 Conclusion: Neonates with KMP showed immunological abnormalities, including decreases in helper T cells and B cells. Prolonged APTT and elevated ferritin were identified as independent risk factors for severe thrombocytopenia in KMP.

Indexed as

Kasabach-Merritt SyndromeThrombocytopeniaFemaleHumansInfant, NewbornMalePlatelet CountRetrospective StudiesSeverity of Illness Indexclinical characteristicshemangiomaimmunological featuresKasabach-Merritt phenomenonneonatessevere thrombocytopenia

Identifiers

PMID42445171
PMCPMC13357802

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