ArticleGland surgery2026
A nomogram-based risk stratification strategy to optimize central lymph node dissection in cN1a papillary thyroid cancer with Hashimoto's thyroiditis.
Article in Gland surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Preoperative assessment of central lymph node metastasis (CLNM) in cN1a papillary thyroid cancer (PTC) with Hashimoto's thyroiditis (HT) is challenging due to inflammatory interference. Thus, this study aimed to establish a nomogram-based risk stratification strategy to optimize central lymph node dissection (CLND). Methods: We retrospectively analyzed patients diagnosed with cN1a stage PTC at our hospital from 2015 to 2025. General information and ultrasound characteristics were collected, and patients were categorized based on their HT status and CLNM status. Logistic regression analysis was performed, and a predictive nomogram for CLNM was developed and validated. Results: HT significantly increased the false-positive rate of CLNM (24.7% Conclusions: Preoperative cN1a staging is frequently confounded by HT-related inflammatory lymphadenopathy, necessitating a more nuanced diagnostic approach. Our nomogram effectively stratifies the risk of true CLNM in this population, and serves as an auxiliary tool to provide decision-making advice for CLND.
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