ArticleRegenerative biomaterials2026
A degradable hydrogel scaffold incorporating the LL-37 for gingival soft tissue regeneration.
Article in Regenerative biomaterials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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13 authors.
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Abstract
Gingival recession exposes the roots, leads to dentin hypersensitivity, and heightens the progression of periodontitis, and poses a threat to oral health and appearance. Conventional treatment uses autogenous palatal grafts, requiring a second surgical site and adding patient discomfort. To overcome autograft limitations, this study developed a hydrogel scaffold as a potential biomaterial candidate for gingival soft tissue augmentation. We developed a multifunctional HA/SF hydrogel scaffold by incorporating EGCG and the antimicrobial peptide LL-37. It exhibits antibacterial, anti-inflammatory, antioxidant and pro-angiogenic activities. Its 3D network mimics the native extracellular matrix (ECM), enables minimally invasive delivery and conforms to irregular root surfaces.
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