ArticleACS medicinal chemistry letters2026
The Development of UM-232, a Covalent STING Antagonist.
Article in ACS medicinal chemistry letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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12 authors.
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Abstract
The cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway is a central regulator of innate immunity, sensing cytosolic DNA and initiating inflammatory signaling. Aberrant activation of this pathway drives autoimmune and inflammatory pathologies, positioning STING as a compelling therapeutic target. Here, we describe the structure-activity relationship (SAR)-guided optimization of
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