Evidence map›Paper›PMID 42445001›Full record

ArticleACS medicinal chemistry letters2026

Synthesis of Nitazoxanide Derivatives as Potent and Orally Available HBx-DDB1 Inhibitors against Hepatitis B Virus.

Seong Gon Kim, Hyeon-Min Cha, Minwoo Kim, Inseong Jo, Soo Bong Han, Meehyein Kim, Wonseo Park, Youyoung Kim, Chunkyu Ko, Dong-Su Kim

Abstract read
In one paragraph

Article in ACS medicinal chemistry letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Seong Gon KimTherapeutics and Biotechnology Division, Korea Research Institute of Chemical Technology, Daejeon 34114, Republic of Korea.
Hyeon-Min ChaTherapeutics and Biotechnology Division, Korea Research Institute of Chemical Technology, Daejeon 34114, Republic of Korea.
Minwoo KimTherapeutics and Biotechnology Division, Korea Research Institute of Chemical Technology, Daejeon 34114, Republic of Korea.
Inseong JoTherapeutics and Biotechnology Division, Korea Research Institute of Chemical Technology, Daejeon 34114, Republic of Korea.ORCID https://orcid.org/0000-0002-7964-4751
Soo Bong HanTherapeutics and Biotechnology Division, Korea Research Institute of Chemical Technology, Daejeon 34114, Republic of Korea.ORCID https://orcid.org/0000-0002-7831-1832
Meehyein KimTherapeutics and Biotechnology Division, Korea Research Institute of Chemical Technology, Daejeon 34114, Republic of Korea.ORCID https://orcid.org/0000-0002-2851-5298
Wonseo ParkTherapeutics and Biotechnology Division, Korea Research Institute of Chemical Technology, Daejeon 34114, Republic of Korea.ORCID https://orcid.org/0009-0006-7011-3467
Youyoung KimTherapeutics and Biotechnology Division, Korea Research Institute of Chemical Technology, Daejeon 34114, Republic of Korea.
Chunkyu KoTherapeutics and Biotechnology Division, Korea Research Institute of Chemical Technology, Daejeon 34114, Republic of Korea.
Dong-Su KimTherapeutics and Biotechnology Division, Korea Research Institute of Chemical Technology, Daejeon 34114, Republic of Korea.ORCID https://orcid.org/0000-0003-0388-4633

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nitazoxanide-based analogues were synthesized and evaluated for HBx-DDB1 interaction inhibition using a split-luciferase assay. Compared to the nitazoxanide (NTZ, IC

Indexed as

ADMETAntiviral agentHBx-DDB1 interactionHepatitis B virusPK

Identifiers

PMID42445001
PMCPMC13358933

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.