ArticleAlcoholism treatment quarterly2025
10-Butyl Ether Minocycline Reduced High Alcohol Consumption in a Dependence Mouse Model.
Article in Alcoholism treatment quarterly, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- 10-Butyl Ether Minocycline (BEM) Reduced Ethanol Consumption in Binge Drinking Mice.Alcoholism treatment quarterly · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
Alcohol use disorder (AUD) poses a significant public health concern, with limited, high-efficacy, treatment options. Our lab has demonstrated that minocycline, an antibiotic with neuroprotective and immunomodulatory properties, is effective in reducing alcohol consumption in rodent models. We then synthesized antimicrobial-free minocycline derivatives to utilize their neuroprotective and immunomodulatory activities while mitigating antibiotic-related side effects. 10-Butyl Ether Minocycline (BEM) was chosen as a lead molecule based on efficacy and physicochemical properties from the library of compounds synthesized. Here, we report that BEM significantly reduced alcohol consumption in the Chronic Intermittent Ethanol (CIE) mouse model of alcohol dependence.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.