ArticleJournal of thoracic disease2026
Dangerous liaisons: the peri-transplant respiratory microbiota and their impact on lung transplantation outcomes.
Article in Journal of thoracic disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
15 authors.
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Abstract
Background: Despite advances in immunosuppression and perioperative care, lung transplantation (LuTX) outcome continues to be limited by allograft rejection and infectious complications. Given the allograft's direct exposure to the environment, peri-transplant microbial presence and dynamics may critically shape outcomes, yet its impact remains incompletely understood. This study aimed to evaluate peri-transplant airway microbiological findings in lung transplant recipients and determine their associations with acute cellular rejection (ACR), chronic lung allograft dysfunction (CLAD), and survival. Methods: We retrospectively analyzed 345 LuTX recipients treated between 2014 and 2019 with follow-up through 2024. Standardized microbiological sampling was performed pre-, intra- and postoperatively. Associations with ACR, CLAD and survival were evaluated. Results: Conclusions: Peri-transplant airway microbiota are significantly associated with graft rejection and survival after LuTX. Donor-derived
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