Evidence map›Paper›PMID 42444971›Full record

ArticleJournal of thoracic disease2026

Gravity-driven modified whole-lung lavage improves procedural efficiency in pulmonary alveolar proteinosis.

Weizhan Luo, Junfeng Huang, Xinyu Song, Changhao Zhong, Xiaobo Chen, Chunli Tang, Liya Lu, Yu Chen, Shiyue Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of thoracic disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Weizhan Luo *State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Department of Respiratory, Guangzhou Institute of Respiratory Health, Department of Respiratory Medicine, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.ORCID https://orcid.org/0000-0002-9174-1423
Junfeng Huang *State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Department of Respiratory, Guangzhou Institute of Respiratory Health, Department of Respiratory Medicine, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Xinyu SongState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Department of Respiratory, Guangzhou Institute of Respiratory Health, Department of Respiratory Medicine, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Changhao ZhongState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Department of Respiratory, Guangzhou Institute of Respiratory Health, Department of Respiratory Medicine, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Xiaobo ChenState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Department of Respiratory, Guangzhou Institute of Respiratory Health, Department of Respiratory Medicine, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Chunli TangState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Department of Respiratory, Guangzhou Institute of Respiratory Health, Department of Respiratory Medicine, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Liya LuDepartment of Anesthesiology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Yu ChenState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Department of Respiratory, Guangzhou Institute of Respiratory Health, Department of Respiratory Medicine, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Shiyue LiState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Department of Respiratory, Guangzhou Institute of Respiratory Health, Department of Respiratory Medicine, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Whole-lung lavage (WLL) remains the gold standard for symptomatic pulmonary alveolar proteinosis (PAP). However, conventional protocols are resource-intensive, relying on manual chest percussion, frequent position changes, and active negative-pressure suctioning to accelerate effluent drainage. We evaluated a modified gravity-driven workflow designed to improve procedural efficiency by optimizing hydrodynamics and minimizing manual airway manipulation. Methods: In this single-center retrospective cohort study, we analyzed 112 WLL procedures performed in 88 patients between October 1, 2007, and April 30, 2024. Procedures were categorized into a classic workflow (n=60; utilizing manual percussion, postural changes, and active negative-pressure suction) or a modified gravity-driven workflow (n=52). The modified technique employed a saline reservoir elevated to 100 cm, fixed supine positioning, and passive gravity drainage through a three-way stopcock to maintain a closed circuit. Primary outcomes included lavage duration, anesthesia duration, and fluid recovery rate. Generalized estimating equations (GEE) were used to adjust for baseline confounders. Results: Baseline characteristics were balanced between groups. The modified technique demonstrated superior efficiency. Compared with the classic technique, the modified workflow significantly reduced the median lavage duration [135 (interquartile range (IQR), 116-160) Conclusions: The gravity-driven modified WLL is an efficient technique. By utilizing increased hydrostatic pressure, this approach significantly reduces procedural time and improves fluid recovery. In this cohort, it was not associated with a detectable difference in short-term oxygenation outcomes or recorded complications.

Indexed as

gravity-drivenprocedural efficiencyPulmonary alveolar proteinosis (PAP)whole-lung lavage (WLL)

Identifiers

PMID42444971
PMCPMC13358599

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.