ArticleFrontiers in oncology2026
Non-gestational choriocarcinoma presenting as cervical lymphadenopathy in a male patient: a case report.
Article in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Non-gestational choriocarcinoma (NGCC) is a rare and highly aggressive malignancy in male patients and is frequently diagnosed at an advanced stage because of its atypical clinical manifestations. We report the case of a 38-year-old male patient who presented a unilateral cervical tumor without associated genitourinary symptoms. Histopathological examination combined with immunohistochemical analysis subsequently confirmed the diagnosis of NGCC. Radiologic assessment demonstrated extensive lymph node involvement without identification of a definite primary lesion. The patient initially showed a transient response following platinum-based chemotherapy, followed by disease progression during follow-up. This case highlights the importance of including NGCC in the differential diagnosis when male patients present with unexplained cervical lymphadenopathy, hemorrhagic and necrotic poorly differentiated tumors, and elevated β-human chorionic gonadotropin (β-hCG) levels. Early recognition together with comprehensive immunohistochemical evaluation and systemic imaging assessment is essential to reduce diagnostic delay.
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