ArticleRheumatology and immunology research2026
MRI-based study of gray matter volume and cortical morphological alterations in patients with rheumatoid arthritis.
Article in Rheumatology and immunology research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To investigate alterations in gray matter volume (GMV) and cortical morphology in patients with rheumatoid arthritis (RA) and examine their associations with clinical characteristics using voxel-based morphometry (VBM) and surface-based morphometry (SBM). Methods: 41 RA patients and 34 age- and sex-matched healthy controls (HCs) underwent high-resolution structural magnetic resonance imaging (sMRI). VBM was used to compare GMV, and SBM was applied to assess gyrification index (GI), cortical thickness (CT), sulcus depth (SD), and fractal dimension (FD). Whole-brain voxel/vertex-wise multiple linear regression analyses evaluated associations between structural indices and DAS28 disease activity scores, Hamilton Depression Scale (HAMD), Hamilton Anxiety Scale (HAMA), Montreal Cognitive Assessment (MoCA), C-reactive protein (CRP), Visual Analogue Scale (VAS), swollen joint count, and tender joint count. Results: No significant group diferences were found in sex (χ Conclusion: Through multi-parameter joint analysis, this study systematically depicted the multi-dimensional changes in brain structure of patients with RA for the first time and initially established a framework for their association with disease activity, emotional and cognitive impairment, and inflammatory levels.
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