Evidence map›Paper›PMID 42444523›Full record

ArticleJournal of pediatric gastroenterology and nutrition2026

Gut microbiome in pediatric acute pancreatitis and Crohn's disease versus irritable bowel syndrome and healthy controls.

Neha R Santucci, Chinenye R Dike, Jenny Hellmann, Nicholas J Ollberding, Qing Duan, Philip Minar, Lee A Denson, David B Haslam, Daniel Castillo, Maisam Abu-El-Haija

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of pediatric gastroenterology and nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Neha R SantucciDivision of Pediatric Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.ORCID https://orcid.org/0000-0002-0896-079X
Chinenye R DikeDepartment of Pediatrics, Division of Pediatric Gastroenterology, Hepatology and Nutrition, The University of Alabama at Birmingham, Birmingham, Alabama, USA.
Jenny HellmannDivision of Pediatric Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Nicholas J OllberdingDepartment of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, Ohio, USA.
Qing DuanDivision of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Philip MinarDivision of Pediatric Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Lee A DensonDivision of Pediatric Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
David B HaslamInfectious Diseases, Cincinnati Children's Hospital Medical Cent, Cincinnati, Ohio, USA.
Daniel CastilloPediatric Gastroenterology, The Nemours Foundation, Jacksonville, Florida, USA.
Maisam Abu-El-HaijaDivision of Pediatric Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.

Funding

Stem Cell/Organoid and Genome Editing CoreP30DK078392 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI LEE ARMISTEAD DENSON · 2007 to 2026
$24.4M
PEDIATRIC GASTROENTEROLOGY AND NUTRITION TRAINING GRANTT32DK007727 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI Phillip P Minar · 1995 to 2026
$11.3M
Predicting Severity and Improving the Outcomes of Pediatric PancreatitisK23DK118190 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI ABU-EL-HAIJA, MAISAM · 2018 to 2022
$947k
Disrupted sleep architecture in adolescents with functional abdominal pain disordersK23DK135797 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI Neha Richard Santucci · 2023 to 2026
$765k
Microbial regulation of intestinal tuft cell homeostasisK01DK135647 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI Emily M. Eshleman · 2023 to 2026
$563k
Using fMRI to understand response to an integrative treatment for pain and anxiety in pediatric functional abdominal pain disorders (FAPD)K23AT009458 · NCCIH · MICHIGAN STATE UNIVERSITY · PI CUNNINGHAM, NATOSHIA RAISHEVICH · 2018 to 2022
$548k
Diabetes Timing and Types and the Effect on Beta Cell Function Post-Acute Pancreatitis in ChildrenR03DK131156 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI ABU-EL-HAIJA, MAISAM · 2022 to 2023
$227k
The Relationship of Circadian Phase and Functional Abdominal Pain in AdolescentsR03DK147916 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI Neha Richard Santucci · 2026 to 2026
$122k
Digestive Diseases Research Core Center in CincinnatiLeona M. and Harry B. Helmsley Charitable Trust for the ENvISION study NCT04131504National Institutes of Health - National Institute of Diabetes and Digestive and Kidney Disease 23DK118190National Institutes of Health - National Institute of Diabetes and Digestive and Kidney Disease K23DK135797National Institutes of Health - National Institute of Diabetes and Digestive and Kidney Disease R03 DK131156NCCIH NIH HHS K23 AT009458NIDDK NIH HHS K01 DK135647NIDDK NIH HHS K23 DK118190NIDDK NIH HHS K23 DK135797NIDDK NIH HHS P30 DK078392NIDDK NIH HHS R03 DK131156NIDDK NIH HHS R03 DK147916NIDDK NIH HHS T32 DK007727NIH HHS P30 DK078392
6 · The paper itself

Abstract

objectivesPediatric acute pancreatitis (AP), Crohn's disease (CD), and irritable bowel syndrome (IBS) are associated with gut dysbiosis, but differences and similarities between conditions are unknown. We hypothesized that gut microbial ecology would differ across these disorders.

methodsStool was collected from 120 subjects (AP [n = 30], CD [n = 29], IBS Rome IV [n = 27], and healthy controls [HC, n = 34]). Shotgun metagenomic sequencing was performed on extracted DNA and taxonomic and functional profiles obtained using sylph and HUMAnN3 with default parameters.

resultsAge interquartile range for all participants was 8.1-17.7 years. Shannon diversity was decreased in AP compared to IBS or HC (p < 0.0001) and similar to CD (p = 0.97). CD differed from IBS (p = 0.001) and HC (p < 0.0001) while IBS and HC were similar (p = 0.61). Ordination of the first two principal coordinate analyses axes showed sample clustering by condition (R

conclusionOrganic disorders (AP and CD) are associated with significant gut dysbiosis than IBS which appears more like HC. Interventions targeting shifts in commensals in AP and CD may be helpful in improving outcomes in both disorders.

Indexed as

Crohn DiseaseDysbiosisGastrointestinal MicrobiomeIrritable Bowel SyndromePancreatitisAcute DiseaseAdolescentCase-Control StudiesChildFecesFemaleHumansMaledisorders of gut–brain interactiondysbiosismetagenomic sequencingorganic disordersshannon diversity

Identifiers

PMID42444523
PMCPMC13646039

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.