ArticleCentral European journal of public health2026
Association between air pollution and paediatric intestinal intussusception in Seoul, Korea: a time-series regression approach.
Article in Central European journal of public health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectivesThe impact of air pollution on gastrointestinal diseases remains unclear. This study examines the association between air pollutants and paediatric intussusception incidence.
methodsUsing data from the Health Insurance Review and Assessment Service (HIRA), we analysed daily intussusception cases in Seoul (2009-2019). Air pollutants, including particulate matter (PM10), ozone (O3), nitrogen dioxide (NO2), carbon monoxide (CO), and sulphur dioxide (SO2), were assessed alongside temperature. A generalized linear model with a negative binomial link function evaluated the relationship between each pollutant and intussusception incidence, adjusting for long-term trends and seasonality. A distributed lag non-linear model (DLNM) examined non-linear cumulative lag effects.
resultsIn the model without lag and non-linear effects, NO2 was significantly associated with intussusception incidence, while other pollutants and temperature showed no significant associations. DLNM analysis with a 3-day cumulative lag demonstrated a gradual increase in intussusception incidence with rising NO2 levels, with significant rate ratio changes at lag 0 and lag 1 but not at lag 2 or lag 3. Extending the cumulative lag to 2, 4 and 5 days showed progressively decreasing significant intervals.
conclusionThese findings suggest a potential link between NO2 exposure and paediatric intussusception. Further studies are needed to clarify underlying mechanisms.
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