The Effect of Chronic Angiotensin (1-7) Treatment on Functional Responses of Isolated Resistance Arteries in Streptozotocin-Induced Diabetic Rats.

Esra Akcabag, Ikbal Ozen Kucukcetin, Gul Ozbey, Sebahat Ozdem, Sadi S Ozdem

Abstract read

In one paragraph

Article in Fundamental & clinical pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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1 · What the graph read from it

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Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Esra AkcabagMedical Faculty, Department of Medical Pharmacology, Akdeniz University, Antalya, Turkiye.ORCID https://orcid.org/0000-0002-6238-8173

Ikbal Ozen KucukcetinMedical Faculty, Department of Medical Biochemistry, Akdeniz University, Antalya, Turkiye.

Gul OzbeyMedical Faculty, Department of Medical Pharmacology, Akdeniz University, Antalya, Turkiye.

Sebahat OzdemMedical Faculty, Department of Medical Biochemistry, Akdeniz University, Antalya, Turkiye.

Sadi S OzdemMedical Faculty, Department of Medical Pharmacology, Akdeniz University, Antalya, Turkiye.ORCID https://orcid.org/0000-0003-4325-5209

Funding

The Scientific Research Projects Coordination Unit of Akdeniz University TDK-2018-4187

6 · The paper itself

Abstract

Cardiovascular complications of diabetes mellitus (DM) are responsible for morbidity and mortality in DM patients. Recent evidence highlights the pathophysiological role of the renin-angiotensin-aldosterone system in DM. This study determined whether chronic angiotensin (1-7) (Ang (1-7); 576 μg/kg, s.c., 4 weeks) treatment improves vascular reactivity in mesenteric small resistance arteries of streptozotocin-induced diabetic rats using a wire myograph system and to investigate the underlying mechanisms. Increased sensitivity to vasoconstrictors and decreased responses to endothelium-dependent vasodilators in diabetic rats compared to control rats were partially reversed by Ang (1-7) treatment. Nω-nitro-L-arginine methyl ester (L-NAME, 10

Indexed as

Angiotensin IDiabetes Mellitus, ExperimentalMesenteric ArteriesPeptide FragmentsVascular ResistanceAnimalsEndothelium, VascularMaleNG-Nitroarginine Methyl EsterNitric OxideRatsRats, WistarStreptozocinVasodilationVasodilator AgentsAngiotensin Iangiotensin I (1-7)NG-Nitroarginine Methyl EsterNitric OxidePeptide FragmentsStreptozocinVasodilator Agentsangiotensin (1–7)diabetes mellitusisolated resistance arteryrenin‐angiotensin‐aldosterone systemwire myograph system

Identifiers

PMID42444408

DOI10.1111/fcp.70107

PMCPMC13366148

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.