Evidence map›Paper›PMID 42444324›Full record

ArticleCell proliferation2026

Wt1 Is Required for the Regression of Müllerian Ducts in Male Mice by Inducing Wif1 and Osx Expression.

Min Chen, Xin Qi, Shanshan Qin, Jia Kang, Changhuo Cen, Miao Guo, Yang Gao, Mengyue Wang, Jiayi Li, Xiuhong Cui and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell proliferation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Min ChenState Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
Xin QiCollege of Veterinary Medicine, Inner Mongolia Agricultural University, Key Laboratory of Clinical Diagnosis and Treatment Technology in Animal Disease, Ministry of Agriculture, Hohhot, China.
Shanshan QinState Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
Jia KangDepartment of Obstetrics and Gynecology, National Clinical Research Center for Obstetric and Gynecologic Diseases, Peking Union Medical College Hospital, State Key Laboratory for Complex Severe and Rare Diseases, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.
Changhuo CenState Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
Miao GuoState Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
Yang GaoState Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
Mengyue WangState Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
Jiayi LiState Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
Xiuhong CuiState Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
Yanbo WangCollege of Life Sciences and Food Engineering, Inner Mongolia Minzu University, Tongliao, Inner Mongolia, China.ORCID https://orcid.org/0000-0001-9335-2264
Lan ZhuDepartment of Obstetrics and Gynecology, National Clinical Research Center for Obstetric and Gynecologic Diseases, Peking Union Medical College Hospital, State Key Laboratory for Complex Severe and Rare Diseases, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.ORCID https://orcid.org/0000-0001-5753-5426
Fei GaoState Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.ORCID https://orcid.org/0000-0002-4029-6411

Funding

Central Government Guiding Funds for Local Science and Technology Development 2023ZY0015Initiative Scientific Research Program, Institute of Zoology, Chinese Academy of Sciences 2023IOZ0102National Natural Science Foundation of China 32270902National Natural Science Foundation of China 32360182National Natural Science Foundation of China 32530031National Natural Science Foundation of China 82421003National Natural Science Foundation of China 82571907the Strategic Priority Research Program of the Chinese Academy of Sciences XDB0820000
6 · The paper itself

Abstract

In mammals, Müllerian ducts (MDs) are the precursors of the female reproductive tract which regress in males during embryonic development. Failure of MD regression results in persistent Müllerian duct syndrome (PMDS) in humans. Although several factors essential for MD regression have been identified, the underlying regulatory network remains incompletely understood. In this study, we found that the Wilms tumour gene (Wt1) was highly expressed in the MD mesenchyme of male mice. Mesenchyme-specific inactivation of Wt1 resulted in MD retention and male infertility. The expression of Amh in the testes and its receptor Amhr2 in the MD mesenchyme remained unchanged in Wt1

Indexed as

Müllerian ductsOsxregressionWif1Wt1

Identifiers

PMID42444324
PMCPMC13366097

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.