Evidence map›Paper›PMID 42444277›Full record

ArticleCell biochemistry and function2026

GRWD1 as a Novel Signature and It Down Regulates IFN in Skin Aging.

Fei Tan, Yaoqun Wang, Peng Xu, Yunjin Li, Yichen Yan, Yutong Gao, Xiaoping Hu, Mengyuan Shen, Qixia Wang, Juan Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell biochemistry and function, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Fei TanShanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China.
Yaoqun WangShanghai Skin Disease Clinical College, The Fifth Clinical Medical College, Anhui Medical University, Shanghai Skin Disease Hospital, Shanghai, China.
Peng XuShanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China.
Yunjin LiShanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China.
Yichen YanDepartment of Ophthalmology of Tongji Hospital and Laboratory of Clinical and Visual Sciences of Tongji Eye Institute, School of Medicine, Tongji University, Shanghai, China.
Yutong GaoDepartment of Ophthalmology of Tongji Hospital and Laboratory of Clinical and Visual Sciences of Tongji Eye Institute, School of Medicine, Tongji University, Shanghai, China.
Xiaoping HuShanghai Skin Disease Clinical College, The Fifth Clinical Medical College, Anhui Medical University, Shanghai Skin Disease Hospital, Shanghai, China.
Mengyuan ShenShanghai Skin Disease Clinical College, The Fifth Clinical Medical College, Anhui Medical University, Shanghai Skin Disease Hospital, Shanghai, China.
Qixia WangDepartment of General Practice, Xi'an Central Hospital, Xi'an, China.
Juan WangDepartment of Ophthalmology of Tongji Hospital and Laboratory of Clinical and Visual Sciences of Tongji Eye Institute, School of Medicine, Tongji University, Shanghai, China.ORCID https://orcid.org/0000-0003-2244-6102

Funding

The Shanghai Shen Kang Clinical Technology Promotion Program (No. SHDC12026111) and The Xi'an Municipal Health Commission General Research Project (No. 2026ms03)
6 · The paper itself

Abstract

Deep mining of the molecular mechanisms underlying skin aging is critical for the development of novel therapeutic targets. The aim of this study was to explore potential key signatures and underlying mechanisms in skin aging. Bioinformatics tools were used to evaluate the differentially expressed genes (DEGs), perform enrichment analysis, and construct protein-protein interaction networks on datasets. The hub genes were identified using Cytoscape software and then confirmed by qRT-PCR and Western Blot in vitro. We focused on the possible roles of GRWD1. GRWD1 expression were suppressed in senescence model of HDF. After GRWD1 overexpression by lentivirus in primary human dermal Fibroblasts (HDF), transcriptome sequencing (RNA-seq) was performed. GRWD1 has influence on the inflammation and immune responses. IFN signaling pathway genes significant increase in senescence HDF. When GRWD1 overexpressed, decreased expression of IFN pathway is validated. Besides, age-related markers p16, IL-6, and IL-8 expression decreased and LaminB expression also increased. It was also proved after GRWD1 knockdown. GRWD1 was identified as a novel signature in skin aging. GRWD1 directly interact with IRF3. GRWD1 overexpression can down regulate IFN signaling pathway key genes expression, further diminish IFN aging-inducing effects. GRWD1 alleviates skin inflammatory responses by suppressing IRF3-mediated IFN pathway activation. Our findings suggest that GRWD1 may serve as a molecular biomarker and further as a potential therapeutic target for skin aging.

Indexed as

Down-RegulationInterferonsSkin AgingCells, CulturedCellular SenescenceFibroblastsHumansInterferon Regulatory Factor-3Signal TransductionInterferon Regulatory Factor-3InterferonsIRF3 protein, humanfibroblastGRWD1IFN pathwayskin aging

Identifiers

PMID42444277
PMCPMC13366027

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.