Evidence map›Paper›PMID 42444256›Full record

ArticleCanadian journal of gastroenterology & hepatology2026

Low-Volume Plasma Exchange Combined With a Double Plasma Molecular Adsorption System is Superior to Standard-Volume Plasma Exchange in improving the MELD Score and Reducing Plasma Consumption in Adult Patients With Acute Liver Failure: A Multicenter Retrospective Cohort Study From Heilongjiang Province.

Yang Liu, Jia-Le Deng, Shu-Xiao Qiu, Di Wu, Hui-Ying Liu, Yu-Jia Tang, Yi-Jin Tang, Zi-Yue Zhang, Qing-Min Meng, Yang Gao and 2 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Canadian journal of gastroenterology & hepatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yang LiuDepartment of Critical Care Medicine, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China, hrbmush.edu.cn.
Jia-Le DengDepartment of Critical Care Medicine, The Sixth Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Shu-Xiao QiuDepartment of Emergency, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China, hrbmu.edu.cn.
Di WuDepartment of Critical Care Medicine, The Sixth Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Hui-Ying LiuDepartment of Critical Care Medicine, The Sixth Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Yu-Jia TangDepartment of Critical Care Medicine, The Sixth Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.ORCID https://orcid.org/0000-0003-4113-0779
Yi-Jin TangDepartment of Critical Care Medicine, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China, hrbmu.edu.cn.
Zi-Yue ZhangDepartment of Critical Care Medicine, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China, hrbmu.edu.cn.
Qing-Min MengDepartment of Critical Care Medicine, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China, hrbmu.edu.cn.
Yang GaoDepartment of Critical Care Medicine, The Sixth Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.ORCID https://orcid.org/0000-0002-0612-0818
Yan GaoDepartment of Critical Care Medicine, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China, hrbmu.edu.cn.ORCID https://orcid.org/0000-0001-5716-7328
Kai KangDepartment of Critical Care Medicine, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China, hrbmu.edu.cn.ORCID https://orcid.org/0000-0001-9694-4505

Funding

Key Research and Development Program of Heilongjiang GA23C007National Natural Science Foundation of China 82372172Natural Science Foundation of Heilongjiang Province JJ2024LH2132Yijiayi Medical Science Research Fund 2024-KY003
6 · The paper itself

Abstract

objectiveThis research aimed to investigate the disparities in improving the model for end-stage liver disease (MELD) score and plasma volume consumption between standard-volume plasma exchange (SVPE) and low-volume plasma exchange (LVPE) combined with the double plasma molecular adsorption system (DPMAS) in adult patients with acute liver failure (ALF).

methodsThis multicenter cohort study retrospectively enrolled adult patients with ALF who were admitted to the designated hospitals and received conventional drug treatment along with one or more sessions of SVPE or LVPE combined with DPMAS during hospitalization. According to the different therapeutic plasma exchange (TPE) methods received during hospitalization, the enrolled patients were subsequently classified into the SVPE group and the LVPE combined with DPMAS group. Thereafter, the aforementioned demographic characteristics, laboratory parameters, their change rates, and plasma consumption were compared between different groups or before and after TPE.

resultsIn this multicenter retrospective cohort study, 97 adult patients with ALF were recruited, with a male-to-female ratio of 1.06: 1. Subsequently, they were classified into the SVPE group (n = 48) and the LVPE combined with DPMAS group (n = 49). During hospitalization, they received a total of 97 sessions of SVPE and 91 sessions of LVPE combined with DPMAS. There were significant differences in multiple laboratory parameters before the first SVPE or LVPE combined with DPMAS between different groups, yet the MELD score was not involved. The change rates of multiple laboratory parameters, including the MELD score, and plasma consumption displayed significant differences between the SVPE group and the LVPE combined with DPMAS group.

conclusionIn terms of improving the MELD score of patients with ALF and reducing the plasma volume, the combined use of LVPE and DPMAS is more effective than SVPE.

Indexed as

Liver Failure, AcutePlasma ExchangeAdultChinaFemaleHumansMaleMiddle AgedPlasma VolumeRetrospective StudiesSeverity of Illness IndexTreatment Outcomeacute liver failureartificial liver support systemsstandard-volume plasma exchange

Identifiers

PMID42444256
PMCPMC13365874

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.