Evidence map›Paper›PMID 42444181›Full record

ArticleBJPsych open2026

Maternal genetic liability for neuroticism and breastfeeding intention, initiation and maintenance.

Elizabeth C Braithwaite, Amy Campbell, Holly Fraser, Nicky Wright, Jasmine Hearn, Jennifer McGahan, Lucy Bowes, Alex S F Kwong, Hannah Sallis, Rebecca M Pearson

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In one paragraph

Article in BJPsych open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

10 authors.

Elizabeth C BraithwaiteSchool of Psychology, https://ror.org/02hstj355Manchester Metropolitan University, UK.ORCID https://orcid.org/0000-0003-4902-2262
Amy CampbellSchool of Psychological Science, University of Bristol, UK.
Holly FraserMedical Research Council (MRC) Integrative Epidemiology Unit, University of Bristol, UK.
Nicky WrightSchool of Psychology, https://ror.org/02hstj355Manchester Metropolitan University, UK.ORCID https://orcid.org/0000-0002-3285-2051
Jasmine HearnSchool of Psychology, https://ror.org/02hstj355Manchester Metropolitan University, UK.
Jennifer McGahanSchool of Psychology, https://ror.org/02hstj355Manchester Metropolitan University, UK.
Lucy BowesDepartment of Experimental Psychology, University of Oxford, UK.
Alex S F KwongCentre for Clinical Brain Sciences, Division of Reproductive and Developmental Sciences, University of Edinburgh, UK.ORCID https://orcid.org/0000-0003-1953-2771
Hannah SallisSchool of Psychological Science, University of Bristol, UK.
Rebecca M PearsonSchool of Psychology, https://ror.org/02hstj355Manchester Metropolitan University, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRelationships between maternal mental health and breastfeeding outcomes are complex, with evidence of bi-directional effects complicated by culturally specific residual confounding and selection bias.

aimsThis study aimed to examine, for the first time, associations between maternal genetic liability for neuroticism and breastfeeding intention, initiation and maintenance.

methodWe used data from the Avon Longitudinal Study of Parents and Children (ALSPAC) prospective birth cohort. Maternal genotype data were used to create polygenic scores (PGS) for neuroticism. Mothers self-reported breastfeeding intentions at 32 weeks gestation, breastfeeding initiation within the first week after birth and maintenance of breastfeeding to 6 months after birth. We examined associations between maternal genetic liability for neuroticism and breastfeeding outcomes by using unadjusted logistic regression models (

resultsThere was evidence that genetic liability for neuroticism was associated with lower odds for breastfeeding maintenance (odds ratio 0.86, 95% CI 0.83-0.94,

conclusionsThe specificity of links between neuroticism and maintenance of breastfeeding could direct targeting of efforts to support women with emotional difficulties in maintaining breastfeeding. This is important because currently, most efforts to support breastfeeding women focus on intention and initiation.

Indexed as

ALSPACbreastfeedingmaternal mental healthNeuroticism

Identifiers

PMID42444181
PMCPMC13372803

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.