Evidence map›Paper›PMID 42444128›Full record

ArticleMolecular therapy : the journal of the American Society of Gene Therapy2026

miR-146a mimic therapy protects against platelet-mediated thrombosis.

Sonia Águila, Juan C García-Cañaveras, Laura Zapata-Martínez, Ana B Arroyo, Nuria García-Barberá, Salvador Carrillo-Tornel, Pedro J Guijarro-Carrillo, Paula González-Jiménez, Ana Latorre, María L Lozano and 8 more

Abstract read
In one paragraph

Article in Molecular therapy : the journal of the American Society of Gene Therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Sonia ÁguilaCentro Regional de Hemodonación, Servicio de Hematología Hospital Universitario Morales Meseguer, IMIB Pascual Parrilla, 30003 Murcia, Spain; Universidad de Murcia, 30100 Murcia, Spain; ImuBi, Universidad de Murcia, 30100 Murcia, Spain. Electronic address: sonia.aguila@um.es.
Juan C García-CañaverasBiomarkers and Precision Medicine Unit, Instituto de Investigación Sanitaria Fundación Hospital La Fe, 46026 Valencia, Spain.
Laura Zapata-MartínezCentro Regional de Hemodonación, Servicio de Hematología Hospital Universitario Morales Meseguer, IMIB Pascual Parrilla, 30003 Murcia, Spain.
Ana B ArroyoCentro Regional de Hemodonación, Servicio de Hematología Hospital Universitario Morales Meseguer, IMIB Pascual Parrilla, 30003 Murcia, Spain.
Nuria García-BarberáCentro Regional de Hemodonación, Servicio de Hematología Hospital Universitario Morales Meseguer, IMIB Pascual Parrilla, 30003 Murcia, Spain.
Salvador Carrillo-TornelCentro Regional de Hemodonación, Servicio de Hematología Hospital Universitario Morales Meseguer, IMIB Pascual Parrilla, 30003 Murcia, Spain.
Pedro J Guijarro-CarrilloCentro Regional de Hemodonación, Servicio de Hematología Hospital Universitario Morales Meseguer, IMIB Pascual Parrilla, 30003 Murcia, Spain.
Paula González-JiménezPneumology Department, La Fe University and Polytechnic Hospital, 46026 Valencia, Spain; Respiratory Infections, Health Research Institute La Fe (IISLAFE), 46026 Valencia, Spain; Medicine Department, University of Valencia. 46026 Valencia, Spain.
Ana LatorreRespiratory Infections, Health Research Institute La Fe (IISLAFE), 46026 Valencia, Spain.
María L LozanoCentro Regional de Hemodonación, Servicio de Hematología Hospital Universitario Morales Meseguer, IMIB Pascual Parrilla, 30003 Murcia, Spain; Universidad de Murcia, 30100 Murcia, Spain; ImuBi, Universidad de Murcia, 30100 Murcia, Spain.
Bernard PayrastreINSERM, UMR-S U1297 and University of Toulouse III, Institute of Cardiovascular and Metabolic Diseases (I2MC), CHU-Rangueil, 31432 Toulouse, France; Laboratoire d'Hématologie, CHU de Toulouse, 31059 Toulouse Cedex, France.
José RiveraCentro Regional de Hemodonación, Servicio de Hematología Hospital Universitario Morales Meseguer, IMIB Pascual Parrilla, 30003 Murcia, Spain; Universidad de Murcia, 30100 Murcia, Spain; ImuBi, Universidad de Murcia, 30100 Murcia, Spain.
Marie-Pierre GratacapINSERM, UMR-S U1297 and University of Toulouse III, Institute of Cardiovascular and Metabolic Diseases (I2MC), CHU-Rangueil, 31432 Toulouse, France.
Raúl MéndezPneumology Department, La Fe University and Polytechnic Hospital, 46026 Valencia, Spain; Respiratory Infections, Health Research Institute La Fe (IISLAFE), 46026 Valencia, Spain; Medicine Department, University of Valencia. 46026 Valencia, Spain; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, 28029 Madrid, Spain.
Agustín LahozBiomarkers and Precision Medicine Unit, Instituto de Investigación Sanitaria Fundación Hospital La Fe, 46026 Valencia, Spain.
Marcin KortylewskiCenter for Gene Therapy and Department of Immuno-Oncology, Beckman Research Institute at City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA.
Rocío González-ConejeroCentro Regional de Hemodonación, Servicio de Hematología Hospital Universitario Morales Meseguer, IMIB Pascual Parrilla, 30003 Murcia, Spain; Universidad de Murcia, 30100 Murcia, Spain; ImuBi, Universidad de Murcia, 30100 Murcia, Spain. Electronic address: rociogon@um.es.
Constantino MartínezCentro Regional de Hemodonación, Servicio de Hematología Hospital Universitario Morales Meseguer, IMIB Pascual Parrilla, 30003 Murcia, Spain; ImuBi, Universidad de Murcia, 30100 Murcia, Spain. Electronic address: constant@um.es.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

miR-146a exhibits variable expression levels in humans due to rs2431697, which is associated with cardiovascular events. However, the functional mechanisms linking this genotype with the occurrence of thrombotic events remain unknown. Here, we found that miR-146a partial deficiency was associated with increased platelet activation and a higher incidence of cardiovascular events during hospitalization in patients with community-acquired pneumonia. Accordingly, platelets from miR-146a

Indexed as

Blood PlateletsMicroRNAsThrombosisAnimalsCarnitine O-PalmitoyltransferaseDisease Models, AnimalFatty AcidsHumansMiceMice, KnockoutPlatelet ActivationPlatelet AggregationCarnitine O-PalmitoyltransferaseFatty AcidsMicroRNAsMirn146 microRNA, mousecommunity-acquired pneumoniafatty acid oxidationmetabolismmiRNAsmouse modelplateletstherapythrombosis

Identifiers

PMID42444128
PMCPMC13555580

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.