Evidence map›Paper›PMID 42444006›Full record

ReviewStem cell research & therapy2026

Immunomodulatory efficacy of culture condition-dependent modulation of mesenchymal stem cells.

Qiuli Sun, Xi Zhang, Huixian Dong, Chunliu Mi, Shaolei Geng, Qin Li, Jihong Zhang, Xiaoyin Wang, Tianyun Wang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Stem cell research & therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Qiuli SunSchool of Life Science and Technology, Henan Medical University, Xinxiang, 453003, China.
Xi ZhangInternational Joint Research Laboratory for Recombinant Pharmaceutical Protein Expression System of Henan, Henan Medical University, Xinxiang, 453003, China.
Huixian DongSchool of Life Science and Technology, Henan Medical University, Xinxiang, 453003, China.
Chunliu MiInternational Joint Research Laboratory for Recombinant Pharmaceutical Protein Expression System of Henan, Henan Medical University, Xinxiang, 453003, China.
Shaolei GengInternational Joint Research Laboratory for Recombinant Pharmaceutical Protein Expression System of Henan, Henan Medical University, Xinxiang, 453003, China.
Qin LiInternational Joint Research Laboratory for Recombinant Pharmaceutical Protein Expression System of Henan, Henan Medical University, Xinxiang, 453003, China.
Jihong ZhangInternational Joint Research Laboratory for Recombinant Pharmaceutical Protein Expression System of Henan, Henan Medical University, Xinxiang, 453003, China.
Xiaoyin WangInternational Joint Research Laboratory for Recombinant Pharmaceutical Protein Expression System of Henan, Henan Medical University, Xinxiang, 453003, China.
Tianyun WangInternational Joint Research Laboratory for Recombinant Pharmaceutical Protein Expression System of Henan, Henan Medical University, Xinxiang, 453003, China. wtianyuncn@126.com.ORCID https://orcid.org/0000-0002-0793-1006

Funding

National Natural Science Foundation of China 32401271National Natural Science Foundation of China 82304369National Natural Science Foundation of China U23A20270Natural Science Foundation of Henan Province 232300421115Natural Science Foundation of Henan Province 252300421678Provincial Science and Technology Research and Development Program Joint Fund 235101610005
6 · The paper itself

Abstract

Mesenchymal stem cells (MSCs), due to their unique anti-inflammatory, immunosuppressive, immunomodulatory, and regenerative properties, have been used in the treatment of various diseases. Despite the advancements in the technological development of culture media and cell cultures, ensuring that MSCs have immune regulatory functions while maintaining their application remains challenging. In this review, factors that affect the proliferation, stemness, immune regulation, and paracrine properties of MSCs in culture are summarized, and divided into three groups: culture environment, cytokines, and chemical additives. Understanding the factors that affect the immune regulatory properties of MSCs in culture will contribute to the large-scale cultivation of MSCs, in order to obtain high-quality MSCs for disease treatment.

Indexed as

Cell Culture TechniquesImmunomodulationMesenchymal Stem CellsAnimalsCell ProliferationCulture MediaCytokinesHumansCulture MediaCytokinesChemical additivesCulture environmentCytokinesImmune regulationMesenchymal stem cells

Identifiers

PMID42444006
PMCPMC13644215

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.