Evidence map›Paper›PMID 42443996›Full record

ArticleBiomarker research2026

Interleukin-10 enhances IgG galactosylation and sialylation.

Hanna B Lunding, Anna M Wasynczuk, Yannic C Bartsch, Jana Sophia Buhre, Jan Nouta, Alexei Leliavski, Selina Lehrian, Anna Emilia Becker, Kristina Manzhula, Philipp Köcher and 4 more

Abstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomarker research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Hanna B LundingLaboratory of Immunology, Institute of Nutritional Medicine, University of Luebeck and University Hospital Schleswig-Holstein, Campus Luebeck, Luebeck, Germany.
Anna M WasynczukCenter for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, The Netherlands.
Yannic C BartschLaboratory of Immunology, Institute of Nutritional Medicine, University of Luebeck and University Hospital Schleswig-Holstein, Campus Luebeck, Luebeck, Germany.
Jana Sophia BuhreLaboratory of Immunology, Institute of Nutritional Medicine, University of Luebeck and University Hospital Schleswig-Holstein, Campus Luebeck, Luebeck, Germany.
Jan NoutaCenter for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, The Netherlands.
Alexei LeliavskiLaboratory of Immunology, Institute of Nutritional Medicine, University of Luebeck and University Hospital Schleswig-Holstein, Campus Luebeck, Luebeck, Germany.
Selina LehrianLaboratory of Immunology, Institute of Nutritional Medicine, University of Luebeck and University Hospital Schleswig-Holstein, Campus Luebeck, Luebeck, Germany.
Anna Emilia BeckerLaboratory of Immunology, Institute of Nutritional Medicine, University of Luebeck and University Hospital Schleswig-Holstein, Campus Luebeck, Luebeck, Germany.
Kristina ManzhulaLaboratory of Immunology, Institute of Nutritional Medicine, University of Luebeck and University Hospital Schleswig-Holstein, Campus Luebeck, Luebeck, Germany.
Philipp KöcherLaboratory of Immunology, Institute of Nutritional Medicine, University of Luebeck and University Hospital Schleswig-Holstein, Campus Luebeck, Luebeck, Germany.
Janina MehlfeldLaboratory of Immunology, Institute of Nutritional Medicine, University of Luebeck and University Hospital Schleswig-Holstein, Campus Luebeck, Luebeck, Germany.
Johann RahmöllerLaboratory of Immunology, Institute of Nutritional Medicine, University of Luebeck and University Hospital Schleswig-Holstein, Campus Luebeck, Luebeck, Germany.
Manfred WuhrerCenter for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, The Netherlands. m.wuhrer@lumc.nl.
Marc EhlersLaboratory of Immunology, Institute of Nutritional Medicine, University of Luebeck and University Hospital Schleswig-Holstein, Campus Luebeck, Luebeck, Germany. marc.ehlers@uksh.de.ORCID https://orcid.org/0000-0002-5383-8603

Funding

Deutsche Forschungsgemeinschaft 390884018
6 · The paper itself

Abstract

IgG antibodies contain a conserved N-linked glycosylation site at Asn297 in the Fc region, and variations in Fc glycosylation critically influence antibody effector functions. While inflammatory signals during immunization are known to reduce IgG Fc galactosylation and sialylation, the counter-regulatory pathways that enhance these modifications remain poorly understood. Here, we investigated the association of the anti-inflammatory cytokine IL-10 with germinal center (GC) responses and IgG Fc glycosylation following protein immunization in mice. Blockade of IL-10 receptor signaling after immunization with a model protein and the adjuvant Alum reduced Fc galactosylation and sialylation of antigen-specific IgG1 and was associated with decreased expression of the sialyltransferase St6gal1 in antigen-specific GC B cells and plasma cells. Although IFNγ is known to suppress IgG Fc galactosylation and sialylation, Alum immunization paradoxically induced both high levels of Fc galactosylation and sialylation as well as a high frequency of IFNγ-producing CD4

Indexed as

B cellGerminal centerIFNγIgG galactosylationIgG glycosylationIgG sialylationInterleukin-10Plasma cellT follicular cell

Identifiers

PMID42443996
PMCPMC13366667

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.