Evidence map›Paper›PMID 42443902›Full record

ArticleJournal of nanobiotechnology2026

VSIG3 preserves mitochondrial homeostasis and restrains CD4⁺ T-Cell infiltration in myocardial ischemia-reperfusion injury through regulation of mitochondrial-derived vesicles.

Jian Hou, Liqun Shang, Zi Yan, Yuanhan Ao, Wanying Chen, Pei Lin, Jiarui Liu, Xintong Wang, Zhaojin Li, Huayang Li and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Jian Hou *Department of Cardiac Surgery, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510080, China.
Liqun Shang *Department of Cardiac Surgery, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510080, China.
Zi Yan *Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, 510120, China.
Yuanhan Ao *Department of Cardiac Surgery, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510080, China.
Wanying ChenGuangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, 510632, PR China.
Pei LinGuangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, 510632, PR China.
Jiarui LiuDepartment of Immunology, School of Medicine, Jinan University, Guangzhou, 510632, China.
Xintong WangDepartment of Cardiovascular Medicine, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510145, China.
Zhaojin LiGuangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, 510632, PR China.
Huayang LiDepartment of Cardiac Surgery, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510080, China.
Quan LiuDepartment of Cardiac Surgery, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510080, China.
Yi ZhangDepartment of Cardiac Surgery, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510080, China.
Jianping YaoDepartment of Cardiac Surgery, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510080, China.
Can GaoDepartment of Cardiac Surgery, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510080, China.
Junyou ZhuDepartment of Burns, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, China. zhujy73@mail.sysu.edu.cn.
Shiyu LiDepartment of Immunology, School of Medicine, Jinan University, Guangzhou, 510632, China. lishiyu@jnu.edu.cn.
Suiqing HuangDepartment of Cardiac Surgery, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510080, China. huangsuiqing@126.com.
Zhongkai WuDepartment of Cardiac Surgery, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510080, China. wuzhk@mail.sysu.edu.cn.

Funding

Basic and Applied Basic Research Foundation of Guangdong Province 2025A1515012604Fundamental Research Funds for the Central Universities 21624220National Center for Translational Medicine (Shanghai) SHU Branch of Shanghai University SUITM-202503National Key Research and Development Program of China 2023YFC2706200National Natural Science Foundation of China 82300018National Natural Science Foundation of China 82370271National Natural Science Foundation of China 82572913National Natural Science Foundation of China U23A20500The Key Medical Disciplines and Specialities Program of Guangzhou 2025-2027
6 · The paper itself

Abstract

Myocardial ischemia-reperfusion (MI/R) injury remains an inevitable and severe clinical challenge during cardiac surgery, primarily characterized by mitochondrial dysfunction and robust CD4

Indexed as

CD4-Positive T-LymphocytesMembrane ProteinsMitochondriaMyocardial Reperfusion InjuryAnimalsApoptosisCytokinesExtracellular VesiclesHomeostasisHumansMaleMiceMice, Inbred C57BLMyocardiumPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktCytokinesMembrane ProteinsPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktTOR Serine-Threonine KinasesCD4+ T-CellExtracellular vesiclesMitochondrial dysfunctionMyocardial ischemia-reperfusionPI3K/Akt/mTORVSIG3

Identifiers

PMID42443902
PMCPMC13644124

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.