Evidence map›Paper›PMID 42443875›Full record

ArticleBMC ophthalmology2026

Anterior horizontal rectus anatomy in children with concomitant strabismus.

Shuqi You, Yuanhao Wu, Xiaojing Cai, Li Shen, Zhenxuan Zhou, Yaohui Gong, Tiancheng Wu, Xiaohong Zhou, Chenhao Yang

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Article in BMC ophthalmology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

9 authors.

Shuqi YouDepartment of Ophthalmology, Children's Hospital of Fudan University, 399 Wanyuan Road, Shanghai, 201102, China.
Yuanhao WuCiya Technology Co., Ltd., 185 Moyu Road, Shanghai, 200000, China.
Xiaojing CaiDepartment of Ophthalmology, Children's Hospital of Fudan University, 399 Wanyuan Road, Shanghai, 201102, China.
Li ShenDepartment of Ophthalmology, Children's Hospital of Fudan University, 399 Wanyuan Road, Shanghai, 201102, China.
Zhenxuan ZhouDepartment of Ophthalmology, Children's Hospital of Fudan University, 399 Wanyuan Road, Shanghai, 201102, China.
Yaohui GongDepartment of Ophthalmology, Children's Hospital of Fudan University, 399 Wanyuan Road, Shanghai, 201102, China.
Tiancheng WuDepartment of Ophthalmology, Children's Hospital of Fudan University, 399 Wanyuan Road, Shanghai, 201102, China.
Xiaohong ZhouDepartment of Ophthalmology, Children's Hospital of Fudan University, 399 Wanyuan Road, Shanghai, 201102, China. 081024026@fudan.edu.cn.
Chenhao YangDepartment of Ophthalmology, Children's Hospital of Fudan University, 399 Wanyuan Road, Shanghai, 201102, China. ychben@hotmail.com.

Funding

Children's Hospital of Fudan University EKSJD202412
6 · The paper itself

Abstract

backgroundAnterior ciliary vessel (ACV) counts, tendon width (TW), and limbus-to-insertion distance (LID) describe vascular, structural, and positional features of the anterior horizontal rectus. Data integrating these parameters in children with concomitant strabismus remain limited. We aimed to characterize ACV counts, TW, and LID in pediatric horizontal concomitant strabismus and examine their associations with diagnosis and clinical variables.

methodsIn this hospital-based cross-sectional study, 227 children undergoing primary horizontal rectus surgery were included. ACV bundles were quantified from intraoperative images, and TW and LID were measured. Esotropia-exotropia comparisons were performed within measured muscle subsets. Exploratory analyses examined associations with deviation magnitude, age, and axial length (AL), with false discovery rate (FDR) correction. Multivariable linear regression adjusted comparisons for age and AL. Logistic regression was performed in cases with complete measurements of both horizontal rectus muscles.

resultsThe mean age was 7.31 ± 3.18 years. ACV-count patterns differed between the medial rectus (MR) and lateral rectus (LR), but not by diagnosis or deviation magnitude; 59.18% of LRs had two ACV bundles. Mean TW was 9.98 ± 0.65 mm for the MR and 9.60 ± 0.64 mm for the LR. Mean LID was 5.44 ± 0.38 mm for the MR and 6.84 ± 0.40 mm for the LR. After adjustment for age and AL, the crude LR width difference between exotropia and esotropia was attenuated (P = 0.212), whereas MR insertion remained shorter in esotropia (P = 0.022). LR width showed positive associations with age (P < 0.001) and AL (P = 0.004). Narrower MR width showed nominal associations with larger exodeviations in large-angle exotropia and did not remain significant after FDR correction. In restricted logistic regression, more anterior MR insertion was associated with esotropia (P = 0.033).

conclusionsIn pediatric concomitant horizontal strabismus, LR ACV bundles were more frequent than traditionally described, LR width appeared influenced by age and AL, and MR LID was shorter in esotropia than in exotropia. These integrated anatomical findings provide a useful surgical anatomical reference for children and may help frame future studies of esotropia-exotropia mechanisms and postoperative response.

Indexed as

Oculomotor MusclesStrabismusAdolescentChildChild, PreschoolCiliary BodyCross-Sectional StudiesEsotropiaExotropiaFemaleHumansMaleOphthalmologic Surgical ProceduresTendonsVision, BinocularChildCiliary arteriesEsotropiaExotropiaOculomotor musclesStrabismusTendons

Identifiers

PMID42443875
PMCPMC13647595

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.