Evidence map›Paper›PMID 42443837›Full record

ArticleBMC public health2026

Psychiatric factors associated with early-onset and poly-drug use: insights from a large-scale addiction registry.

Zohreh Manoochehri, Samaneh Nakhaee, Borhan Mansouri, Adeleh Elahi, Omran Davarinejad, Sana Karimi, Zana Ramazani

Abstract read
In one paragraph

Article in BMC public health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zohreh Manoochehri *Substance Abuse Prevention Research Center, Research Institute for Health, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Samaneh Nakhaee *Medical Toxicology and Drug Abuse Research Center, Birjand University of Medical Sciences, Birjand, Iran.
Borhan MansouriSubstance Abuse Prevention Research Center, Research Institute for Health, Kermanshah University of Medical Sciences, Kermanshah, Iran. borhanmansouri@yahoo.com.
Adeleh ElahiClinical Research Development Center, Imam Khomeini and Mohammad Kermanshahi and Farabi Hospitals, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Omran DavarinejadClinical Research Development Center, Imam Khomeini and Mohammad Kermanshahi and Farabi Hospitals, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Sana KarimiStudent Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Zana RamazaniSubstance Abuse Prevention Research Center, Research Institute for Health, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Funding

Kermanshah University of Medical Sciences 4040296
6 · The paper itself

Abstract

BACKGROUND AND

aimsEarly initiation of substance use and concurrent use of multiple drugs are critical factors linked to adverse health outcomes. Thus, this study aimed to investigate the demographic, behavioral, and psychiatric associates of early-onset and poly-drug use among individuals with substance use disorders in Western Iran.

methodsIn this cross-sectional study, data were collected from the Addiction Disorders Registry of inpatients admitted to Farabi Hospital in Kermanshah, Iran. A total of 1,030 individuals diagnosed with substance use disorders were included in the analysis. Data were gathered through structured clinical interviews and reviews of medical records. Statistical analyses included descriptive statistics, chi-square tests, t-tests, Mann-Whitney U tests, and logistic regression models.

resultsParticipants who began using substances before the age of 18 had a significantly lower mean age. Poly-drug users also tended to be younger. Logistic regression analysis indicated that male gender, being single, curiosity-driven initiation of use, and the presence of bipolar or personality disorders were significantly associated with early-onset substance use. Additionally, poly-drug use was associated with younger age, male gender, divorced marital status, and the presence of depressive disorders.

conclusionDemographic and psychiatric characteristics linked to early initiation and poly-drug use. These findings underscore the need for targeted prevention and intervention strategies that focus on vulnerable subgroups.

Indexed as

Mental DisordersSubstance-Related DisordersAdolescentAdultAge of OnsetCross-Sectional StudiesFemaleHumansIranMaleMiddle AgedRegistriesRisk FactorsYoung AdultDemographicsEarly onsetIranPoly-drug usePsychiatric comorbiditySubstance use disorders

Identifiers

PMID42443837
PMCPMC13643959

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.