Evidence map›Paper›PMID 42443742›Full record

ArticleBMC genomics2026

Single-nucleus transcriptomic atlas of postnatal camel liver development identifies candidate adaptive features.

Huiquan Shan, Ao Zhang, Haotian Li, Tao Shi, Yongqing Li, Weiwei Wu, Xihong Wang

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Article in BMC genomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

7 authors.

Huiquan Shan *Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, 712100, China.
Ao Zhang *Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, 712100, China.
Haotian LiKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, 712100, China.
Tao ShiKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, 712100, China.
Yongqing LiInstitute of Animal Science, Xinjiang Academy of Animal Science, Urumqi, 830011, China.
Weiwei WuInstitute of Animal Science, Xinjiang Academy of Animal Science, Urumqi, 830011, China.
Xihong WangKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, 712100, China. wxh@nwafu.edu.cn.

Funding

National Natural Science Foundation of China W2512088
6 · The paper itself

Abstract

backgroundCamels possess distinctive physiological traits related to metabolism and environmental resilience, highlighting the need to characterize liver cellular composition in this species.

resultsWe used single-nucleus RNA sequencing to generate a developmental atlas of the Bactrian camel (Camelus bactrianus) liver using one individual from each of the newborn, weaning, and adult stages, analyzing 57,036 cells and identifying 19 cell types, including hepatocytes, liver sinusoidal endothelial cells (LSECs), and immune cells. We identified a unique subtype of HGFAC+ LSECs that was not observed in the available cattle or human datasets, characterized by high expression of hepatocyte growth factor activator (HGFAC), which is known to activate hepatocyte growth factor (HGF). Hepatocyte pseudotime ordering was consistent with a putative transition from proliferation-associated states toward metabolically annotated states. In the samples collected in this study, Kupffer cells were more represented in the newborn sample, whereas T-cell subsets were more represented in the adult sample. Exploratory cross-species mapping indicated shared transcriptional features between several adult camel and cattle immune cells.

conclusionsThese results suggest liver biochemical features that may contribute to camel resilience to arid conditions, providing a resource for further studies of camel liver biology and livestock adaptation to harsh environments.

Indexed as

CamelusLiverTranscriptomeAnimalsAnimals, NewbornCattleEndothelial CellsGene Expression ProfilingHepatocytesSingle-Cell Gene Expression AnalysisCamelHepatocyteLiver developmentLiver sinusoidal endothelial cellSingle-nucleus RNA sequencing

Identifiers

PMID42443742

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