Evidence map›Paper›PMID 42443722›Full record

ArticleAging cell2026

Aging Enhances Serotonergic Signaling via 5-HT

Qiaofeng Zhao, Alberto Leguina-Ruzzi, Mitsutoshi Tominaga, Yayoi Kamata, Atsuko Kamo, Huiying Wan, Bin Yin, Yuping Ran, Kenji Takamori

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging cell, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Qiaofeng ZhaoJuntendo Itch Research Center (JIRC), Institute for Environmental and Gender-Specific Medicine, Juntendo University, Chiba, Japan.ORCID https://orcid.org/0000-0001-7407-4043
Alberto Leguina-RuzziFaculty of Medicine, Universidad Andrés Bello, Santiago, Chile.ORCID https://orcid.org/0000-0002-4761-3491
Mitsutoshi TominagaJuntendo Itch Research Center (JIRC), Institute for Environmental and Gender-Specific Medicine, Juntendo University, Chiba, Japan.ORCID https://orcid.org/0000-0002-1254-1803
Yayoi KamataJuntendo Itch Research Center (JIRC), Institute for Environmental and Gender-Specific Medicine, Juntendo University, Chiba, Japan.
Atsuko KamoGraduate School of Health Care and Nursing, Juntendo University, Chiba, Japan.ORCID https://orcid.org/0000-0002-4930-2523
Huiying WanDepartment of Dermatology, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.ORCID https://orcid.org/0000-0003-2036-6360
Bin YinWest China School of Medicine, Sichuan University, Sichuan University Affiliated Chengdu Second People's Hospital, Chengdu, China.
Yuping RanDepartment of Dermatology, West China Hospital, Sichuan University, Chengdu, China.ORCID https://orcid.org/0000-0002-9382-0571
Kenji TakamoriJuntendo Itch Research Center (JIRC), Institute for Environmental and Gender-Specific Medicine, Juntendo University, Chiba, Japan.ORCID https://orcid.org/0000-0002-0644-0504

Funding

Grant-in-Aid for Challenging Research (Exploratory) 24k22237Grant-in-Aid for Challenging Research (Exploratory) 25K22714Grant-in-Aid for Early Career Scientists 23K15292Grant-in-Aid for Scientific Research (B) 23K20320Grant-in-Aid for Scientific Research (B) 23K24217
6 · The paper itself

Abstract

Chronic pruritus (or itch) is a common condition associated with aging; however, the neural mechanisms driving age-related itch hypersensitivity remain largely unknown. Here, we investigated the role of serotonergic signaling in modulating itch sensitivity during aging. Aged mice exhibited enhanced mechanical alloknesis without changes in spontaneous scratching behavior, indicating that aging selectively affects mechanically evoked itch. Consistent with this phenotype, aged mice showed elevated urinary serotonin levels and increased expression of the serotonin receptor 5-HT

Indexed as

AgingPruritusReceptors, SerotoninSerotoninSignal TransductionAnimalsGanglia, SpinalMaleMiceMice, Inbred C57BLReceptors, SerotoninSerotoninserotonin 7 receptor5‐HT7 receptoragingchronic pruritusdorsal root ganglionmechanical alloknesisserotonin signalingspinal dorsal horn

Identifiers

PMID42443722
PMCPMC13364993

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.