ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2026
Factors associated with medication adherence to endocrine therapy in women with breast cancer: an analysis based on temporal self-regulation theory.
Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeSome patients with breast cancer show low adherence to endocrine therapy (ETs). The Temporal self-regulation theory (TST) can explain adherence to medication behavior. Using TST to demonstrate medication adherence in patients with cancer has not been previously investigated. This study aimed to describe the behavior of ET adherence in women with breast cancer and examine the factors affecting health behaviors by applying the TST model.
methodsA cross-sectional study design was used to collect data on connectedness beliefs, temporal valuations, intentions, self-regulatory capacity, behavioral prepotency, and ET adherence among 222 women with breast cancer.
resultsApproximately one in seven women with breast cancer had low ET adherence. Under the guidance of the TST, it was found that factors directly influencing ET adherence included connectedness beliefs-barriers, intention, self-regulatory capacity, and behavioral prepotency. Both self-regulatory capacity and behavioral prepotency partially mediated the relationship between intention and medication adherence. Benefits and barriers to connectedness beliefs indirectly affected medication adherence through intentions. There were no significant moderators.
conclusionsThis finding indicated that connectedness beliefs, intention, self-regulatory capacity, and behavioral prepotency are important factors of ET adherence. Future clinical interventions may target these specific psychological and behavioral mechanisms to effectively promote ET adherence in women with breast cancer.
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