ArticleNeurochemical research2026
Grape Seed Proanthocyanidin Extract (GSPE) Mitigates Preterm White Matter Injury in Mice Via Improving Mitochondrial Homeostasis and Activity of IMMP2L-Related Signaling Pathway.
Article in Neurochemical research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
Grape seed proanthocyanidins extract (GSPE) has demonstrated significant neuroprotective efficacy in various neurodevelopmental disorders, nevertheless its potential beneficial role in preterm white matter injury (PWMI) remains unclear. This study aims to evaluate the therapeutic potential of GSPE against PWMI and the underlying mechanisms. GSPE (20 mg/Kg) was taken orally by the mouse after PWMI modeling. The survival rate, incidence of macroscopic lesions, body weight change were calculated. The myelin damage was evaluated. Mitochondrial homeostasis was detected in PWMI model mice and cultured oligodendrocyte precursor cells (OPCs). Brain tissues from mice groups underwent RNA-seq. A dual-luciferase reporter assay was employed to validate the direct binding interaction between miR-153 and IMMP2L mRNA. The results showed that treatment of GSPE ameliorated cerebral ischemic injury in PWMI mice and improved behaviour ability and cognition deficits. GSPE restored mitochondria homeostasis in both PWMI mice and OPCs. Additionally, IMMP2L was found to be increased, while ROS was diminished by GSPE intervention. KEGG analysis showed that Wnt signaling pathway, the downstream of IMMP2L, changed significantly in PWMI group, while GSPE reversed it. The dual-luciferase reporter assay demonstrated that miR-153-3p directly suppressed IMMP2L expression through these binding sites. In summary, our findings revealed that GSPE treatment alleviated PWMI and restored mitochondrial homeostasis in mice.These beneficial effects are likely be attributed to the improvement of the activity of IMMP2L-related signaling pathways by GSPE.
Indexed as
Identifiers
42443612What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.