Evidence map›Paper›PMID 42443608›Full record

ArticleInflammopharmacology2026

The methanolic extract of Byrsonima intermedia mitigates colonic injury in experimental colitis through redox restoration, cytokine modulation, and tissue repair.

Karla Stella Figueiredo Romano, Felipe Leonardo Fagundes, Quélita Cristina Pereira, Maycon Tavares Emílio-Silva, Larissa Lucena Périco, Vinicius Peixoto Rodrigues, Gabriela Bueno, Mateus Magami Yoshitani, Giovana Pacciulli Pereira, José Aires Pereira and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Inflammopharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Karla Stella Figueiredo RomanoLaboratory of Natural Products, Post Graduate Program in Health Sciences, São Francisco University, Bragança Paulista, São Paulo, 12900-560, Brazil.
Felipe Leonardo FagundesLaboratory of Natural Products, Post Graduate Program in Health Sciences, São Francisco University, Bragança Paulista, São Paulo, 12900-560, Brazil.
Quélita Cristina PereiraLaboratory of Natural Products, Post Graduate Program in Health Sciences, São Francisco University, Bragança Paulista, São Paulo, 12900-560, Brazil.
Maycon Tavares Emílio-SilvaDepartment of Physiology, Institute of Bioscience, São Paulo State University, Botucatu, São Paulo, 18618-689, Brazil.
Larissa Lucena PéricoSnyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, 3330 Hospital Drive NW, Calgary, AB, T2N 4N1, Canada.
Vinicius Peixoto RodriguesDepartment of Physiology, Institute of Bioscience, São Paulo State University, Botucatu, São Paulo, 18618-689, Brazil.
Gabriela BuenoDepartment of Physiology, Institute of Bioscience, São Paulo State University, Botucatu, São Paulo, 18618-689, Brazil.
Mateus Magami YoshitaniLaboratory of Medical Investigation, São Francisco Medical School, Post Graduate Program in Health Sciences, Bragança Paulista, São Paulo, 12900-560, Brazil.
Giovana Pacciulli PereiraLaboratory of Medical Investigation, São Francisco Medical School, Post Graduate Program in Health Sciences, Bragança Paulista, São Paulo, 12900-560, Brazil.
José Aires PereiraLaboratory of Medical Investigation, São Francisco Medical School, Post Graduate Program in Health Sciences, Bragança Paulista, São Paulo, 12900-560, Brazil.
Carlos Augusto Real MartinezLaboratory of Medical Investigation, São Francisco Medical School, Post Graduate Program in Health Sciences, Bragança Paulista, São Paulo, 12900-560, Brazil.
Alessandra GamberoLife Science School, Pontifical Catholic University of Campinas, Campinas, 13087-571, Brazil.
Clélia Akiko Hiruma-LimaDepartment of Physiology, Institute of Bioscience, São Paulo State University, Botucatu, São Paulo, 18618-689, Brazil. clelia.hiruma@unesp.br.
Raquel de Cássia Dos SantosLaboratory of Natural Products, Post Graduate Program in Health Sciences, São Francisco University, Bragança Paulista, São Paulo, 12900-560, Brazil.ORCID http://orcid.org/0000-0002-3195-8188

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study evaluated the anti-inflammatory and antioxidant effects of a methanolic extract of Byrsonima intermedia leaves (EBi) in a rat model of 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis. Male Wistar rats received intracolonic TNBS for lesion induction and relapse, followed by oral treatment with EBi for seven days. EBi markedly reduced the severity of colonic injury, as demonstrated by a 63% decrease in macroscopic damage, along with reductions in inflammatory infiltrate (32%) and neutrophil accumulation (52%) compared to the vehicle group. These protective effects were accompanied by significant attenuation of myeloperoxidase (MPO) activity and lipid peroxidation, together with increased superoxide dismutase (SOD) activity and glutathione levels (GSH), indicating restoration of redox homeostasis. EBi also modulated key inflammatory mediators, promoting IL-10 upregulation while downregulating IL-1β, MCP-1, and TLR4 expression in colonic tissue. Histological analysis confirmed substantial improvement in tissue architecture and inflammatory status. Collectively, these findings demonstrate that B. intermedia exerts multi-target anti-inflammatory and antioxidant actions that contribute to tissue repair in experimental colitis, supporting its potential as a promising natural therapeutic candidate for inflammatory bowel disease.

Indexed as

ColitisColonCytokinesPlant ExtractsAnimalsAnti-Inflammatory AgentsAntioxidantsDisease Models, AnimalLipid PeroxidationMaleMethanolOxidation-ReductionPlant LeavesRatsRats, WistarTrinitrobenzenesulfonic AcidAnti-Inflammatory AgentsAntioxidantsCytokinesMethanolPlant ExtractsTrinitrobenzenesulfonic AcidAnti-inflammatory activityByrsonima intermediaCytokine modulationRedox homeostasisTNBS-induced colitis

Identifiers

PMID42443608
PMCPMC13525043

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.