Observational studyDiabetes, obesity & metabolism2026
Fractional Excretion of Total Protein and Long-Term Kidney Outcomes in Patients With Biopsy-Proven Diabetic Nephropathy: The N-BDN Study.
Observational study in Diabetes, obesity & metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- Fractional Excretion of Total Protein and Long-Term Kidney Outcomes in Patients With Biopsy-Proven Diabetic Nephropathy: The N-BDN Study.Diabetes, obesity & metabolism · 2026Observational
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
aimsProteinuria is a standard predictor for kidney prognosis in patients with diabetic nephropathy (DN). Even among patients with similar levels of proteinuria, the protein load per functioning nephron can vary substantially depending on the total number of functioning nephrons. We examined whether fractional excretion of total protein (FETP), which reflects the protein load per single functioning nephron, provides superior prognostic value for kidney outcomes compared with conventional proteinuria in DN. MATERIALS AND
methodsThis observational study included patients with biopsy-proven DN at our institution between June 1981 and December 2014. The primary focus was the incremental prognostic value of adding FETP, compared with proteinuria, to a baseline clinical model for predicting kidney failure requiring replacement therapy (KFRT). Improvements in model discrimination and risk reclassification were quantified using the concordance index (C-index), net reclassification improvement (NRI), and integrated discrimination improvement (IDI).
resultsThis study included 376 patients with biopsy-proven DN (median age: 59 years; 62.5% male; median estimated glomerular filtration rate, 58.1 mL/min/1.73 m
conclusionsFETP was independently associated with KFRT in patients with DN and may provide additional prognostic information beyond conventional proteinuria for risk stratification.
trial registrationUMIN000031121 (University Hospital Medical Information Network).
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