Evidence map›Paper›PMID 42443586›Full record

ReviewRheumatology international2026

Surgical management of autoimmune-associated calcinosis: a dermatomyositis case and case-based review.

Melina Yerolatsite, Lamprina Magkou, Konstantinos Seretis, Nikolaos Zintziovas, Anastasia K Zikou, Paraskevi V Voulgari

Abstract readCase ReportsReview
In one paragraph

Review in Rheumatology international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Melina YerolatsiteDepartment of Medical Oncology, University Hospital of Ioannina, Ioannina, Greece.ORCID http://orcid.org/0009-0007-6325-8649
Lamprina MagkouDepartment of Rheumatology, School of Health Sciences, University of Ioannina, 45110, Ioannina, Greece.ORCID http://orcid.org/0009-0002-7637-7317
Konstantinos SeretisDepartment of Plastic Surgery, Medical School, University of Ioannina, Ioannina, Greece.ORCID http://orcid.org/0000-0002-1844-1264
Nikolaos ZintziovasDepartment of Rheumatology, School of Health Sciences, University of Ioannina, 45110, Ioannina, Greece.ORCID http://orcid.org/0009-0000-9528-0583
Anastasia K ZikouDepartment of Radiology, Medical School, University of Ioannina, Ioannina, Greece.ORCID http://orcid.org/0009-0005-8134-9128
Paraskevi V VoulgariDepartment of Rheumatology, School of Health Sciences, University of Ioannina, 45110, Ioannina, Greece. pvoulgar@uoi.gr.ORCID http://orcid.org/0000-0002-5193-2284

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Calcinosis cutis is a challenging complication of autoimmune connective tissue diseases, particularly dermatomyositis, and is associated with significant morbidity. Current medical treatments often show limited and inconsistent effectiveness, highlighting the need to better define the role of alternative approaches. To present a case of extensive dermatomyositis-associated calcinosis successfully managed with surgical excision and flap reconstruction, and to systematically review the role of surgical management in autoimmune-related calcinosis. A case report is presented together with a literature review conducted according to PRISMA guidelines. PubMed, Scopus, DOAJ and the Cochrane Library were searched from inception to June 21, 2026 for studies reporting surgical management of calcinosis in autoimmune connective tissue diseases. A total of 13 case reports and 3 case series were identified, including predominantly female patients with a median age of 55.3 years. Surgical intervention was mainly performed in symptomatic cases, such as pain, infection, or functional impairment. Overall, surgery was associated with pain relief and functional improvement, although recurrence and complications, including wound healing issues, were reported. Pharmacological therapies demonstrated variable and generally limited efficacy. Data on reconstructive techniques were scarce; however, available evidence suggests that flap reconstruction and grafting may improve outcomes in complex cases. Surgical management may represent a valuable treatment option for selected patients with calcinosis associated with autoimmune diseases, particularly in refractory or symptomatic cases. Reconstructive techniques may further enhance functional outcomes, although evidence remains limited. An individualized, multidisciplinary approach is recommended, and further studies are needed to establish optimal management strategies. Registration PROSPERO (CRD420261359925).

Indexed as

Autoimmune DiseasesCalcinosisCalcinosis CutisDermatomyositisFemaleHumansMiddle AgedSurgical FlapsTreatment OutcomeAutoimmune diseasesCalcinosis cutisConnective tissue diseasesDermatomyositisPlastic surgery procedureSurgical flaps

Identifiers

PMID42443586
PMCPMC13364807

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.