Evidence map›Paper›PMID 42443582›Full record

ArticleNature metabolism2026

The perineurium integrates leptin with its sympathetic outflow to protect against obesity.

Gitalee Sarker, Emma Haberman, Anandhakumar Chandran, Thomas Monfeuga, Cyrielle Maroteau, Sofia Lundh, David S Oliveira, Andrea Raimondi, Karin Ziegler, Tiago Gomes and 17 more

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

27 authors.

Gitalee SarkerDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-2175-8705
Emma HabermanDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.
Anandhakumar ChandranResearch and Development, Novo Nordisk Research Centre Oxford, Oxford, UK.
Thomas MonfeugaResearch and Development, Novo Nordisk Research Centre Oxford, Oxford, UK.ORCID http://orcid.org/0000-0003-1564-3474
Cyrielle MaroteauResearch and Development, Novo Nordisk Research Centre Oxford, Oxford, UK.
Sofia LundhDepartment of Pathology and Imaging, Global Drug Discovery, Novo Nordisk, Måløv, Denmark.ORCID http://orcid.org/0000-0002-4552-0312
David S OliveiraDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0003-2530-6666
Andrea RaimondiExperimental Imaging Centre, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Karin ZieglerInstitute of Pharmacology and Toxicology, Technical University Munich (TUM), Munich, Germany.ORCID http://orcid.org/0009-0002-9364-3349
Tiago GomesInstituto de Tecnologia Química e Biológica António Xavier, ITQB NOVA, Lisbon, Portugal.ORCID http://orcid.org/0000-0002-3238-290X
Tiago N CordeiroInstituto de Tecnologia Química e Biológica António Xavier, ITQB NOVA, Lisbon, Portugal.
Karishma ParekhDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.
Emilia SchmidDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0001-8214-6756
Paola Fernández-SanmartínNeurobesity Group, Department of Physiology, Center for Research in Molecular Medicine and Chronic Diseases (CiMUS), Universidade de Santiago de Compostela, Santiago, Spain.ORCID http://orcid.org/0000-0002-5793-271X
Alina GriebelInstitute of Pharmacology and Toxicology, Technical University Munich (TUM), Munich, Germany.
Noelia Martinez-SanchezOxford Centre for Diabetes, Endocrinology and Metabolism, Oxford, UK.ORCID http://orcid.org/0000-0003-4580-8196
Bernardo A ArúsHelmholtz-Zentrum Dresden-Rossendorf (HZDR), Dresden, Germany.
Samson W CheungDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.
Yitao ZhuDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.
Michal ShakedResearch and Development, Novo Nordisk Research Centre Oxford, Oxford, UK.
Sarah C L KnowlesDepartment of Biology, University of Oxford, Oxford, UK.
Stefan Hanns EngelhardtInstitute of Pharmacology and Toxicology, Technical University Munich (TUM), Munich, Germany.ORCID http://orcid.org/0000-0001-5378-8661
Matteo IannaconeVita-Salute San Raffaele University, Milan, Italy.ORCID http://orcid.org/0000-0002-9370-2671
Philipp E SchererTouchstone Diabetes Center, The University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID http://orcid.org/0000-0003-0680-3392
Miguel LópezNeurobesity Group, Department of Physiology, Center for Research in Molecular Medicine and Chronic Diseases (CiMUS), Universidade de Santiago de Compostela, Santiago, Spain.ORCID http://orcid.org/0000-0002-7823-1648
Enrique M ToledoResearch and Development, Novo Nordisk Research Centre Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-1460-4708
Ana I DomingosDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK. ana.domingos@dpag.ox.ac.uk.ORCID http://orcid.org/0000-0002-7938-4814

Funding

Wellcome Trust
6 · The paper itself

Abstract

The regulatory mechanism of leptin's afferent action in the brain is contingent upon the efferent sympathetic innervation of white and brown adipose tissues. Nonetheless, the peripheral regulation governing the afferent-efferent balance remains ambiguous. Here we show the enriched expression of both leptin receptor (Lepr) and β

Indexed as

LeptinObesityPeripheral NervesSympathetic Nervous SystemAnimalsEnergy MetabolismGanglia, SympatheticHumansMaleMiceMice, KnockoutReceptors, Adrenergic, beta-2Receptors, LeptinThermogenesisADRB2 protein, mouseLeptinleptin receptor, mouseReceptors, Adrenergic, beta-2Receptors, Leptin

Identifiers

PMID42443582
PMCPMC13400315

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.