Evidence map›Paper›PMID 42443567›Full record

ArticleNeurochemical research2026

Standardized Extract of Ginkgo biloba L. Reverses Memory Impairment in Older Female Mice with Basal Forebrain Cholinergic Dysfunction.

Beatriz G Muratori, Carlos R Caetano, Irina Emanuela T da Veiga, Andressa G Soliani, Sofia M S E Silva, Juliana P Gava, Lucinéia F Ceridório, Luciano Caselli, Rodrigo P Ureshino, Carla M Prado and 1 more

Abstract read
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In one paragraph

Article in Neurochemical research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Beatriz G MuratoriGraduate Program of Structural and Functional Biology, Federal University of São Paulo, São Paulo, SP, Brazil.
Carlos R CaetanoDepartment of Biological Sciences, Chemical and Pharmaceutical Sciences, Federal University of São Paulo-Institute of Environmental, Campus Diadema, Diadema, SP, Brazil.
Irina Emanuela T da VeigaDepartment of Biological Sciences, Chemical and Pharmaceutical Sciences, Federal University of São Paulo-Institute of Environmental, Campus Diadema, Diadema, SP, Brazil.
Andressa G SolianiGraduate Program of Chemical Biology, Federal University of São Paulo, São Paulo, SP, Brazil.
Sofia M S E SilvaDepartment of Biological Sciences, Chemical and Pharmaceutical Sciences, Federal University of São Paulo-Institute of Environmental, Campus Diadema, Diadema, SP, Brazil.
Juliana P GavaDepartment of Chemistry, Institute of Environmental, Chemical and Pharmaceutical Sciences, Federal University of São Paulo, Campus Diadema, Diadema, SP, Brazil.
Lucinéia F CeridórioDepartment of Chemistry, Institute of Environmental, Chemical and Pharmaceutical Sciences, Federal University of São Paulo, Campus Diadema, Diadema, SP, Brazil.
Luciano CaselliDepartment of Chemistry, Institute of Environmental, Chemical and Pharmaceutical Sciences, Federal University of São Paulo, Campus Diadema, Diadema, SP, Brazil.
Rodrigo P UreshinoDepartment of Biological Sciences, Chemical and Pharmaceutical Sciences, Federal University of São Paulo-Institute of Environmental, Campus Diadema, Diadema, SP, Brazil.
Carla M PradoDepartment of Biosciences, Federal University of São Paulo, Campus Baixada Santista, Santos, SP, Brazil.
Suzete Maria CeruttiGraduate Program of Structural and Functional Biology, Federal University of São Paulo, São Paulo, SP, Brazil. smcerutti@unifesp.br.ORCID http://orcid.org/0000-0002-5246-6721

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aging induces neurochemical changes, particularly in the dentate gyrus (DG), that impair memory. In late-onset Alzheimer's disease (LOAD), neuronal loss in regions like the entorhinal cortex (EC) and hippocampus proper (HP), along with amyloid-β (Aβ) plaques, tau tangles, and reduced cholinergic signaling, accelerates cognitive decline. Building on our group's previous findings of cognitive benefits and neuroprotection from Ginkgo biloba L. leaf extract (EGb), and considering the limited success of current therapies, EGb has emerged as a promising multi-target strategy for reversing memory impairments. This study evaluates the effects of chronic EGb treatment on memory, anxiety-like behaviors, and motor activity in older female wild-type and VAChT knockdown KD

Indexed as

Memory DisordersPlant ExtractsProsencephalonAgingAmyloid beta-PeptidesAnimalsFemaleGinkgo bilobaGinkgo ExtractMiceMice, Inbred C57BLPeptide Fragmentstau ProteinsVesicular Acetylcholine Transport ProteinsAmyloid beta-Peptidesamyloid beta-protein (1-42)Ginkgo biloba extractGinkgo ExtractPeptide FragmentsPlant Extractstau ProteinsVesicular Acetylcholine Transport ProteinsAcetylcholineAgingAmyloid-β1−42EGbHippocampuspTauT231

Identifiers

PMID42443567
PMCPMC13364894

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.