ArticleRheumatology international2026
Intra-articular VEGF inhibition attenuates cartilage degeneration in a rat model of post-traumatic osteoarthritis: a pilot histopathological study.
Article in Rheumatology international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Comparative Histopathological Effects of Intra-Articular Bevacizumab, Ranibizumab, and Aflibercept in Experimental Osteoarthritis.Journal of clinical medicine · 2026Article
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5 authors.
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Abstract
Osteoarthritis (OA) is a progressive joint disease characterized by cartilage degeneration, subchondral bone remodelling, and pathological synovial changes. Vascular endothelial growth factor (VEGF) plays a central role in the neovascularization that drives OA pathophysiology, making VEGF blockade a candidate disease-modifying strategy. To evaluate the histopathological effects of intra-articular bevacizumab, a VEGF inhibitor, on cartilage integrity in a surgically induced rat model of post-traumatic osteoarthritis. Post-traumatic OA was induced by creating full-thickness osteochondral defects in the medial femoral condyles of Wistar albino rats. As both hind limbs were used, individual joints served as the unit of histological analysis. Joints were allocated to four groups: sham (n = 2 joints), OA control (n = 8 joints), bevacizumab 1.25 mg/mL (n = 7 joints), and bevacizumab 2.5 mg/mL (n = 4 joints). Group sizes were unequal owing to tissue loss during histological processing. Bevacizumab (Avastin
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