ArticleCell research2026
Genome-wide profiling of histone modifications and transcription factor binding at single-cell resolution by DeChIC-seq.
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Article in Cell research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- A clearer view of PRSS56 in eyes with myopia.Cell research · 2026Article
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Authors and funding
20 authors.
Zhifei Shi *Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Clinical and Translation Research Center, Shanghai First Maternity and Infant Hospital, School of Life Science and Technology, Tongji University, Shanghai, China.
Xiyang Chen *Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Clinical and Translation Research Center, Shanghai First Maternity and Infant Hospital, School of Life Science and Technology, Tongji University, Shanghai, China.
Yijia YangShanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Clinical and Translation Research Center, Shanghai First Maternity and Infant Hospital, School of Life Science and Technology, Tongji University, Shanghai, China.
Ang WuShanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Clinical and Translation Research Center, Shanghai First Maternity and Infant Hospital, School of Life Science and Technology, Tongji University, Shanghai, China.
Heng WangShanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Clinical and Translation Research Center, Shanghai First Maternity and Infant Hospital, School of Life Science and Technology, Tongji University, Shanghai, China.
Kai ChenShanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Clinical and Translation Research Center, Shanghai First Maternity and Infant Hospital, School of Life Science and Technology, Tongji University, Shanghai, China.
Chong LiShanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Clinical and Translation Research Center, Shanghai First Maternity and Infant Hospital, School of Life Science and Technology, Tongji University, Shanghai, China.ORCID 0000-0002-2862-1357
Lina ZouVazyme Biotech Co., Ltd., Nanjing, Jiangsu, China.
Zhipeng QuVazyme Biotech Co., Ltd., Nanjing, Jiangsu, China.
Yuyan ZhaoShanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Clinical and Translation Research Center, Shanghai First Maternity and Infant Hospital, School of Life Science and Technology, Tongji University, Shanghai, China.
Wenjing GanShanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Clinical and Translation Research Center, Shanghai First Maternity and Infant Hospital, School of Life Science and Technology, Tongji University, Shanghai, China.
Shuhui LiShanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Clinical and Translation Research Center, Shanghai First Maternity and Infant Hospital, School of Life Science and Technology, Tongji University, Shanghai, China.
Jiayu ChenShanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Clinical and Translation Research Center, Shanghai First Maternity and Infant Hospital, School of Life Science and Technology, Tongji University, Shanghai, China.ORCID 0000-0003-4755-8901
Wenqiang LiuShanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Clinical and Translation Research Center, Shanghai First Maternity and Infant Hospital, School of Life Science and Technology, Tongji University, Shanghai, China.ORCID 0000-0002-5974-9900
Jiejun ShiKey Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of the Ministry of Education, Department of Orthopedics, Tongji Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, China.ORCID 0000-0001-9777-1183
Hong WangShanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Clinical and Translation Research Center, Shanghai First Maternity and Infant Hospital, School of Life Science and Technology, Tongji University, Shanghai, China.
Jia-Min ZhangKey Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of the Ministry of Education, Department of Orthopedics, Tongji Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, China. zhangjiamin@tongji.edu.cn.ORCID 0000-0001-5919-002X
Chenfei WangKey Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of the Ministry of Education, Department of Orthopedics, Tongji Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, China. 08chenfeiwang@tongji.edu.cn.ORCID 0000-0001-7573-3768
Shaorong GaoShanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Clinical and Translation Research Center, Shanghai First Maternity and Infant Hospital, School of Life Science and Technology, Tongji University, Shanghai, China. gaoshaorong@tongji.edu.cn.ORCID 0000-0003-1041-3928
Xiaoyu LiuShanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Clinical and Translation Research Center, Shanghai First Maternity and Infant Hospital, School of Life Science and Technology, Tongji University, Shanghai, China. liuxiaoyu@tongji.edu.cn.ORCID 0000-0001-6622-9316
Funding
Ministry of Science and Technology of the People's Republic of China (Chinese Ministry of Science and Technology) 2022YFA1106000National Natural Science Foundation of China (National Science Foundation of China) 32330030National Natural Science Foundation of China (National Science Foundation of China) 32370868National Natural Science Foundation of China (National Science Foundation of China) 32488101
Abstract
Mapping of protein-DNA interactions at single-cell resolution remains a central challenge in epigenomics, particularly for transcription factors (TFs), whose sparse binding limits reliable detection. Here, we establish DeChIC-seq (DNA Deaminase-based Chromatin Immuno-Conversion sequencing), a conversion-based strategy that uses a protein A-DddA
Indexed as
Histone CodeHistonesSingle-Cell AnalysisTranscription FactorsAnimalsBinding SitesChromatinChromatin Immunoprecipitation SequencingMiceProtein BindingChromatinHistonesTranscription Factors
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.