Evidence map›Paper›PMID 42443228›Full record

ArticleNature communications2026

Epigenetic signatures mark early peripheral human B lineage bifurcation and differential transcriptional profiles in mature populations.

Chiara Dionisi, Audrey Kelly, Michael J Pitcher, Sherine H Kottoor, Alana Dalton, Lucia Montorsi, Pawan Dhami, Michelle Kleeman, Richard J Ellis, Cynthia Bishop and 4 more

Abstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Chiara DionisiSchool of Immunology and Microbial Sciences, King's College London, London, UK.
Audrey KellySchool of Immunology and Microbial Sciences, King's College London, London, UK.
Michael J PitcherSchool of Immunology and Microbial Sciences, King's College London, London, UK.ORCID http://orcid.org/0000-0002-1935-2968
Sherine H KottoorSchool of Immunology and Microbial Sciences, King's College London, London, UK.
Alana DaltonSchool of Immunology and Microbial Sciences, King's College London, London, UK.
Lucia MontorsiSchool of Immunology and Microbial Sciences, King's College London, London, UK.
Pawan DhamiGenomics Research Platform and Single Cell Laboratory at Guy's and St Thomas' NHS Foundation Trust, London, UK.ORCID http://orcid.org/0000-0002-5408-1833
Michelle KleemanGenomics Research Platform and Single Cell Laboratory at Guy's and St Thomas' NHS Foundation Trust, London, UK.ORCID http://orcid.org/0000-0002-6984-9454
Richard J EllisAdvanced Cytometry Platform, Guy's and St Thomas' NHS Foundation Trust, London, UK.ORCID http://orcid.org/0000-0002-7459-8485
Cynthia BishopAdvanced Cytometry Platform, Guy's and St Thomas' NHS Foundation Trust, London, UK.ORCID http://orcid.org/0009-0006-1104-596X
Jahangir SufiAdvanced Cytometry Platform, Guy's and St Thomas' NHS Foundation Trust, London, UK.ORCID http://orcid.org/0000-0002-4563-5531
Deena L Gibbons *School of Immunology and Microbial Sciences, King's College London, London, UK.ORCID http://orcid.org/0000-0002-7953-3576
Paul Lavender *School of Immunology and Microbial Sciences, King's College London, London, UK.ORCID http://orcid.org/0000-0001-8710-0263
Jo Spencer *School of Immunology and Microbial Sciences, King's College London, London, UK. jo.spencer@kcl.ac.uk.ORCID http://orcid.org/0000-0002-7202-2431

Funding

RCUK | Medical Research Council (MRC) MR/X000257/1Wellcome TrustWellcome Trust (Wellcome) 220872/Z/20/Z
6 · The paper itself

Abstract

During human B cell maturation, immature transitional (T1) cells transit from bone marrow into the blood. At the subsequent immature T2 stage, a separation into IgM

Indexed as

B-LymphocytesCell LineageEpigenesis, GeneticPrecursor Cells, B-LymphoidAdultCell DifferentiationChromatinFetal BloodGene Expression ProfilingHumansSingle-Cell AnalysisSingle-Cell Gene Expression AnalysisTranscriptomeChromatin

Identifiers

PMID42443228
PMCPMC13487194

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.